<p>Mindfulness and self-compassion are useful skills to advance well-being and avoid mental afflictions. Mindfulness focuses on one’s suffering and how it may be alleviated through eradicating desires and wants. Self-compassion is an openness to and not avoiding one’s suffering. Although research suggests a positive relationship between mindfulness and self-compassion, the variation in correlations is large. Univariate random effects meta-analyses were employed to examine this relationship. Moderators included Age, Publication type, Clinical/Non-Clinical samples, and Mindfulness and Self-Compassion measures. We analyzed 167 samples using total and subscale correlations. Results showed positive and statistically significant (<i>p</i> &lt; .05) associations between mindfulness and self-compassion total score (effect size <i>r</i> = .53; range of <i>r</i> = -.12 to .82). Statistically significant moderators were Mindfulness measures, Self-Compassion measures, Age, Clinical/Non-Clinical samples, and Publication type. The relationships between the subscales of the FFMQ and SCS showed statistically significant and mostly small and medium effect sizes for FFMQ subscales of Acting with Awareness, Nonjudging of Inner Experience, Describing, Observing and Nonreactivity to Inner Experience in relation to the SCS subscales of Self-Kindness, Common Humanity, and Mindfulness. The findings suggest that mindfulness and self-compassion interventions should include age and clinical status.</p>