<p>Inventory management is crucial in organisations, including the Ghana Health Service. This study was carried out to assess the effects of inventory management practices on the healthcare delivery and operational performance of Sunyani Regional Hospital. A descriptive survey research design was used. Fifty respondents were randomly selected from the procurement, pharmacy, store, records, finance, and administration departments. A structured questionnaire was used to collect data for the study. Data analysis was based on frequencies and percentages via the Statistical Package for Social Science (SPSS) software and Excel. The study revealed that the hospital uses suppliers to manage inventory for the hospital (mean = 4.34; SD = 1.10), the hospital has computerised all inventory management systems (mean = 4.30; SD = 1.07), and there is good communication between the hospital and its suppliers (mean = 4.01; SD = 1.05). Moreover, the study revealed that inventory management practices contribute greatly to the healthcare service delivery of Sunyani Regional Hospital (mean = 4.26; SD = 1.09) and help in inventory planning and scheduling in Sunyani Regional Hospital (mean = 4.14; SD = 1.18) and that improved customer service can be realised with proper inventory management at Sunyani Regional Hospital (mean = 4.10; SD = 1.19). The challenges facing the hospital were delays in drug delivery resulting in inadequate inventories (mean = 4.32; SD = 1.42), inadequate funds for procurement (mean = 4.28: SD = 1.84), bureaucratic processes in procurement (mean = 4.25; SD = 1.80), understocking/overstocking (mean = 4.21; SD = 1.62), and conflicts of interest (mean = 4.13; SD = 1.68). The study recommends that the government, together with the Ministry of Health, support the health sector with enough funds to prevent the understanding of health products.</p>