An operator T on \({\mathcal {H}}\) is called pseudo-selfadjoint with S if T is densely defined and there exists a boundedly invertible operator S on \({\mathcal {H}}\) such that \(T^* = STS^{-1}\) . In this paper, we investigate the distance from a pseudo-selfadjoint operator to the set of selfadjoint operators. We also study some conditions for an operator to be selfadjoint when powers of such an operator are pseudo-selfadjoint. Furthermore, we investigate various local spectral properties of pseudo-selfadjoint operators, including hypercyclicity and weak hypercyclicity. In addition, we show that T is an invertible subnormal operator if and only if T admits a Hermitian factorization of the form \(T=AB\) for two selfadjoint operators A and B.