We introduce a class of left ideals (and subalgebras) of nest algebras determined by totally ordered families of partial isometries on a complex Hilbert space H. Let \(\mathcal {E}\) be a family of partial isometries that is totally ordered in the Halmos–McLaughlin ordering, and let \({{\mathcal {A}}}_{\mathcal {E}}\) be the subset of operators in B(H) which, for all \(E\in \mathcal {E}\) , map the initial space of E to the final space of E. We show that \({{\mathcal {A}}}_{\mathcal {E}}\) is a subalgebra of B(H) if and only if \({{\mathcal {A}}}_{\mathcal {E}}\) is a left ideal of a certain nest algebra, and if so, \(\mathcal {E}\) consists of power partial isometries, except possibly for its supremum \(\vee \mathcal {E}\) , in which case the range \(\operatorname {ran}(\vee \mathcal {E})\) is H. It is also shown that any left ideal \({{\mathcal {A}}}_{\mathcal {E}}\) is decomposable and that the subset of finite-rank operators in its closed unit ball is strongly dense in the ball. Necessary and sufficient conditions to solve \(Tx=y\) and \(T^*x=y\) in \({{\mathcal {A}}}_{\mathcal {E}}\) are given.