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<p>This narrative review examines the emerging role of glucagon-like peptide-1 (GLP-1) receptor agonists in reproductive medicine, combining a narrative review of current literature with novel investigational pilot survey data from women seeking fertility care. The survey explores perceptions regarding weight, and weight loss methods including use or awareness of GLP-1. The integration of these perspectives reveals the potential for significant gaps between patient awareness and provider communication regarding these medications, while highlighting their potential therapeutic benefits for obesity-related infertility. A narrative literature review of GLP − 1 receptor agonists in reproductive medicine. An IRB approved anonymous investigational pilot survey to evaluate weight loss perceptions and methods used by those seeking care in a single academic infertility clinic. Narrative literature review with clinic recommendations was completed. Our findings demonstrate that while 86% of patients were aware of GLP-1 medications, only 19.3% had substantive discussions with healthcare providers despite 84.2% attempting weight loss in the past year. This disconnect occurs within a context where emerging evidence suggests GLP-1 receptor agonists may offer unique advantages for fertility optimization through weight loss, metabolic improvement, and potential direct reproductive effects.</p>

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GLP-1 Receptor Agonists in Reproductive Medicine: A Narrative Review and Investigational Pilot Survey of Patient Perspectives in Academic Reproductive Endocrinology

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Alexander L Vlasak,
  • Palm Lindsey,
  • Alexandra Minnihan,
  • Alice Rhoton-Vlasak

摘要

This narrative review examines the emerging role of glucagon-like peptide-1 (GLP-1) receptor agonists in reproductive medicine, combining a narrative review of current literature with novel investigational pilot survey data from women seeking fertility care. The survey explores perceptions regarding weight, and weight loss methods including use or awareness of GLP-1. The integration of these perspectives reveals the potential for significant gaps between patient awareness and provider communication regarding these medications, while highlighting their potential therapeutic benefits for obesity-related infertility. A narrative literature review of GLP − 1 receptor agonists in reproductive medicine. An IRB approved anonymous investigational pilot survey to evaluate weight loss perceptions and methods used by those seeking care in a single academic infertility clinic. Narrative literature review with clinic recommendations was completed. Our findings demonstrate that while 86% of patients were aware of GLP-1 medications, only 19.3% had substantive discussions with healthcare providers despite 84.2% attempting weight loss in the past year. This disconnect occurs within a context where emerging evidence suggests GLP-1 receptor agonists may offer unique advantages for fertility optimization through weight loss, metabolic improvement, and potential direct reproductive effects.