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<p>While <i>Isochrysis zhanjiangensis</i>, a marine microalga, has been widely adopted in aquaculture for its health-promoting properties, its potential as a functional food for human metabolic health remains unexplored. To bridge this gap, this study systematically evaluated the nutritional composition, biosafety, and therapeutic efficacy of <i>I</i>. <i>zhanjiangensis</i> against high-fat diet (HFD)-induced metabolic disorders in mice. Our results revealed that <i>I</i>. <i>zhanjiangensis</i> exhibits a desirable nutritional profile with no detectable toxicity, and its dietary supplementation significantly attenuated HFD-induced metabolic dysregulation. Gut microbiota profiling further demonstrated that <i>I</i>. <i>zhanjiangensis</i> supplementation restored microbial homeostasis, evidenced by mitigation of the elevated Firmicutes/Bacteroidota ratio and enrichment of beneficial genera including <i>Muribaculum</i>, <i>Candidatus</i>_<i>Arthromitus</i>, and <i>Veillonella</i>. Hepatic metabolomics identified key metabolites modulated by <i>I</i>. <i>zhanjiangensis</i>, such as N1-methyl-2-pyridone-5-carboxamide, N-acetyl-L-histidine, and eicosapentaenoic acid, which are mechanistically linked to lipid metabolism regulation. These findings not only position <i>I</i>. <i>zhanjiangensis</i> as a promising candidate for functional food development targeting HFD-induced metabolic dysregulation, but also highlight the untapped potential of aquaculture microalgae as sustainable resources for nutraceutical innovation.</p>

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Isochrysis zhanjiangensis exhibits protective effects against metabolic abnormalities induced by high-fat diet in mice

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • Mei Wu,
  • Yu Bai,
  • Yanrong Li,
  • Kang Chen,
  • Jingyang Le,
  • Jian Li,
  • Chengxu Zhou,
  • Spiros N. Agathos,
  • Lin Zhang,
  • Xiaojun Yan,
  • Jichang Han

摘要

While Isochrysis zhanjiangensis, a marine microalga, has been widely adopted in aquaculture for its health-promoting properties, its potential as a functional food for human metabolic health remains unexplored. To bridge this gap, this study systematically evaluated the nutritional composition, biosafety, and therapeutic efficacy of I. zhanjiangensis against high-fat diet (HFD)-induced metabolic disorders in mice. Our results revealed that I. zhanjiangensis exhibits a desirable nutritional profile with no detectable toxicity, and its dietary supplementation significantly attenuated HFD-induced metabolic dysregulation. Gut microbiota profiling further demonstrated that I. zhanjiangensis supplementation restored microbial homeostasis, evidenced by mitigation of the elevated Firmicutes/Bacteroidota ratio and enrichment of beneficial genera including Muribaculum, Candidatus_Arthromitus, and Veillonella. Hepatic metabolomics identified key metabolites modulated by I. zhanjiangensis, such as N1-methyl-2-pyridone-5-carboxamide, N-acetyl-L-histidine, and eicosapentaenoic acid, which are mechanistically linked to lipid metabolism regulation. These findings not only position I. zhanjiangensis as a promising candidate for functional food development targeting HFD-induced metabolic dysregulation, but also highlight the untapped potential of aquaculture microalgae as sustainable resources for nutraceutical innovation.