Scholarlink

Purpose <p>Type 2 diabetes mellitus (T2DM) with cardiac autonomic neuropathy (CAN) increases cardiovascular risk, yet optimal resistance training intensity remains undefined. This randomized controlled trial examined whether six weeks of high-intensity resistance training (HIRT) improves heart rate variability (HRV) more than moderate-intensity (MIRT), while also assessing cardiac autonomic function, recovery, glycemic control, muscle activity, and health-related quality of life (HRQoL).</p> Methods <p>Forty-three T2DM patients with CAN, diagnosed using Ewings battery test, were randomized to MIRT, HIRT, or control groups using computer generated randomization with allocation concealment. MIRT and HIRT were performed thrice weekly; control group received no intervention. Primary outcomes were HRV and heart rate recovery (HRR). Secondary outcomes included glycemic control, muscle activity, and HRQoL.</p> Results <p>HIRT induced greater improvements than MIRT in SDNN (standard deviation of NN intervals; + 26.7% vs. + 14.3%, <i>P</i> = 0.009) and pNN50 (percentage of successive NN intervals differing by &gt; 50&#xa0;ms; <i>P</i> = 0.008), while RMSSD (root mean square of successive differences) increased in both groups (<i>P</i> &lt; 0.05). LF (low-frequency) power and LF/HF ratio decreased, while TP (total power) and HF (high-frequency) power increased (all <i>P</i> &lt; 0.001), without between-group differences. HIRT reduced peak heart rate (HR), and both groups enhanced early HRR and glycemic control. Muscle activation differed, with HIRT favoring rectus femoris (RF) and MIRT enhanced medial gastrocnemius (GN). HIRT improved physical and social functioning, whereas MIRT reduced physical limitations.</p> Conclusion <p>After 6&#xa0;weeks, HIRT demonstrated greater improvements than MIRT in specific parameters, including SDNN, pNN50, peak HR reduction, RF muscle activation, and certain quality-of-life domains. Both improved early HRR and glycemic control, while MIRT uniquely enhanced GN activation and reduced physical limitations, supporting intensity-tailored resistance training in T2DM with CAN.</p> Trial Registration <p>Prospectively registered in Clinical Trials Registry of India (CTRI/2024/10/075984).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of Moderate-High Intensity Resistance Training on Cardiac Autonomic Modulation, Glycemic Control, Muscle Activity and Quality of Life in Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy: Randomized Controlled Trial

  • 期刊论文

  • 发表日期：

    2026年4月29日

查看全文
  • Pushpa Gupta,
  • Shahid Raza,
  • Aqsa Mujaddadi,
  • Irshad Husain Naqvi

摘要

Purpose

Type 2 diabetes mellitus (T2DM) with cardiac autonomic neuropathy (CAN) increases cardiovascular risk, yet optimal resistance training intensity remains undefined. This randomized controlled trial examined whether six weeks of high-intensity resistance training (HIRT) improves heart rate variability (HRV) more than moderate-intensity (MIRT), while also assessing cardiac autonomic function, recovery, glycemic control, muscle activity, and health-related quality of life (HRQoL).

Methods

Forty-three T2DM patients with CAN, diagnosed using Ewings battery test, were randomized to MIRT, HIRT, or control groups using computer generated randomization with allocation concealment. MIRT and HIRT were performed thrice weekly; control group received no intervention. Primary outcomes were HRV and heart rate recovery (HRR). Secondary outcomes included glycemic control, muscle activity, and HRQoL.

Results

HIRT induced greater improvements than MIRT in SDNN (standard deviation of NN intervals; + 26.7% vs. + 14.3%, P = 0.009) and pNN50 (percentage of successive NN intervals differing by > 50 ms; P = 0.008), while RMSSD (root mean square of successive differences) increased in both groups (P < 0.05). LF (low-frequency) power and LF/HF ratio decreased, while TP (total power) and HF (high-frequency) power increased (all P < 0.001), without between-group differences. HIRT reduced peak heart rate (HR), and both groups enhanced early HRR and glycemic control. Muscle activation differed, with HIRT favoring rectus femoris (RF) and MIRT enhanced medial gastrocnemius (GN). HIRT improved physical and social functioning, whereas MIRT reduced physical limitations.

Conclusion

After 6 weeks, HIRT demonstrated greater improvements than MIRT in specific parameters, including SDNN, pNN50, peak HR reduction, RF muscle activation, and certain quality-of-life domains. Both improved early HRR and glycemic control, while MIRT uniquely enhanced GN activation and reduced physical limitations, supporting intensity-tailored resistance training in T2DM with CAN.

Trial Registration

Prospectively registered in Clinical Trials Registry of India (CTRI/2024/10/075984).