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Purpose <p>Sedentary behavior (SB) and moderate-to-vigorous physical activity (MVPA) are associated with arterial stiffness in the general population. Adults with Down syndrome (DS) reportedly have low MVPA and high SB levels, but less stiff arteries compared to adults without DS (non-DS). We investigated whether the relationship between SB and MVPA levels and arterial stiffness differ between adults with and without DS, and whether age, blood pressure, or body fat percentage (%BF) alter these relationships.</p> Methods <p>Ninety adults (40 DS; 50 non-DS) participated in this study. We measured %BF, mean arterial pressure (MAP), SB and MVPA with accelerometry, and arterial stiffness with carotid-femoral pulse wave velocity (CF-PWV).</p> Results <p>Moderation analysis indicated a significant effect of MVPA on CF-PWV for non-DS (<i>β</i> = − 0.68, <i>P</i> = 0.008), but not adults with DS (<i>β</i> = − 0.15, <i>P</i> = 0.280). There was a significant covariate effect of age on CF-PWV (<i>β</i> = 0.63, <i>P</i> &lt; 0.001), resulting in non-significant interaction between MVPA and DS (<i>P</i> = 0.350). There was significant interaction between age and DS on CF-PWV (<i>P</i> = 0.040) and follow-up analysis showed a smaller effect of age on CF-PWV for adults with (<i>β</i> = 0.48, <i>P</i> &lt; 0.001) than without DS (<i>β</i> = 0.77, <i>P</i> &lt; 0.001).</p> Conclusions <p>The relationship between MVPA and arterial stiffness differs in adults with DS compared to adults without DS. The effect of age on arterial stiffness was lower for adults with DS than adults without DS.</p>

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Differential Influence of Physical Activity on Arterial Stiffness in Adults With and Without Down Syndrome

  • 期刊论文

  • 发表日期：

    2025年5月7日

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  • Brantley K. Ballenger,
  • Stanley P. Brown,
  • Robert W. Motl,
  • Bo Fernhall,
  • Stamatis Agiovlasitis

摘要

Purpose

Sedentary behavior (SB) and moderate-to-vigorous physical activity (MVPA) are associated with arterial stiffness in the general population. Adults with Down syndrome (DS) reportedly have low MVPA and high SB levels, but less stiff arteries compared to adults without DS (non-DS). We investigated whether the relationship between SB and MVPA levels and arterial stiffness differ between adults with and without DS, and whether age, blood pressure, or body fat percentage (%BF) alter these relationships.

Methods

Ninety adults (40 DS; 50 non-DS) participated in this study. We measured %BF, mean arterial pressure (MAP), SB and MVPA with accelerometry, and arterial stiffness with carotid-femoral pulse wave velocity (CF-PWV).

Results

Moderation analysis indicated a significant effect of MVPA on CF-PWV for non-DS (β = − 0.68, P = 0.008), but not adults with DS (β = − 0.15, P = 0.280). There was a significant covariate effect of age on CF-PWV (β = 0.63, P < 0.001), resulting in non-significant interaction between MVPA and DS (P = 0.350). There was significant interaction between age and DS on CF-PWV (P = 0.040) and follow-up analysis showed a smaller effect of age on CF-PWV for adults with (β = 0.48, P < 0.001) than without DS (β = 0.77, P < 0.001).

Conclusions

The relationship between MVPA and arterial stiffness differs in adults with DS compared to adults without DS. The effect of age on arterial stiffness was lower for adults with DS than adults without DS.