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<p>The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a profound global impact on individuals with diabetes mellitus (DM). This review examines the interplay between COVID-19, cholesterol metabolism, and diabetes, focusing on the differences in lipid regulation between Type I (T1DM) and Type II diabetes (T2DM). Diabetes, characterized by impaired glucose regulation and lipid homeostasis, has been identified as a significant risk factor for severe COVID-19 outcomes, including increased rates of hospitalization, ICU admission, and mortality. Dysregulated cholesterol metabolism is often present in diabetic patients and exacerbates the severity of COVID-19. We explore the mechanisms by which SARS-CoV-2 infection affects cholesterol pathways, highlighting the role of cholesterol-rich lipid rafts in viral entry and replication. The review also discusses the potential therapeutic implications of targeting cholesterol metabolism in managing COVID-19 in diabetic populations. Understanding these complex interactions may provide insights into better clinical management strategies and improve outcomes for COVID-19 patients with diabetes.</p>

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COVID-19 and dysregulated cholesterol levels in Type I and Type II diabetes: focus on the difference

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月11日

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  • Ganna Stepanova,
  • Sayam Ghosal

摘要

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a profound global impact on individuals with diabetes mellitus (DM). This review examines the interplay between COVID-19, cholesterol metabolism, and diabetes, focusing on the differences in lipid regulation between Type I (T1DM) and Type II diabetes (T2DM). Diabetes, characterized by impaired glucose regulation and lipid homeostasis, has been identified as a significant risk factor for severe COVID-19 outcomes, including increased rates of hospitalization, ICU admission, and mortality. Dysregulated cholesterol metabolism is often present in diabetic patients and exacerbates the severity of COVID-19. We explore the mechanisms by which SARS-CoV-2 infection affects cholesterol pathways, highlighting the role of cholesterol-rich lipid rafts in viral entry and replication. The review also discusses the potential therapeutic implications of targeting cholesterol metabolism in managing COVID-19 in diabetic populations. Understanding these complex interactions may provide insights into better clinical management strategies and improve outcomes for COVID-19 patients with diabetes.