<p>Behavioral healthcare is critical, yet limited across the country. State legislatures could address gaps through policy processes, but most bills fail. Past research suggests that legislative factors, including sponsor characteristics and presidential administrations, can influence bill outcomes, but the literature is limited regarding (1) which factors predict behavioral health-specific outcomes in state legislatures, and (2) trends in state-level predictors between contrasting presidential administrations. Thus, this study examined state-level behavioral health-related bills, including sponsor-related characteristics, in order to identify any patterns related to bill outcomes. Utilizing a dataset of state-level, behavioral health-related bills introduced during Obama and Trump administrations, this study conducted multilevel logistic regression analyses to determine which legislative factors predicted bill passage and which predictors trended between presidential administrations. This study found that bills passed more frequently if introduced during the Obama administration and/or were introduced by bipartisan sponsors, senators, sponsors in the majority party, sponsors of color, non-Christian-Protestants, older sponsors, and/or Southerners and Westerners. Further, after a presidential administration moderator was introduced, bills passed more frequently during the Obama administration if sponsors were bipartisan, Republican, and/or Midwestern, while during Trump’s administration, bills passed more frequently if introduced by sponsors in the majority party and/or Southerners. Study findings highlight how certain sponsor characteristics as well as presidential administrations may impact the behavioral health policymaking process. Advocates can use these findings when developing advocacy campaigns, targeting sponsors, and choosing tactics when attempting to influence the state-level behavioral health policy process.</p>