<p>To explore accurately influence of recycled fine powder on moisture susceptibility of asphalt mixture, the evaluation test for simulating really water damage was used. The different treated recycled concrete powder was replaced limestone mineral powder in asphalt mixture. The immersion rutting test and Hamburg wheel tracking test were used to study the moisture susceptibility of asphalt mixture with recycled concrete powder, and the correlation of evaluation indicators of different test methods was discussed. The feasibility of immersion rutting test replacement for Hamburg wheel tracking test was analyzed. The influence of fiber, silane coupling agent and aluminium-zirconium coupling agent on asphalt mixture performance was analyzed. The results showed that the limestone mineral powder is replaced by recycled concrete powder, the moisture susceptibility of asphalt mixture with recycled fine powder is damaged, but the moisture susceptibility of asphalt mixture with mechanical activated recycled fine powder is similar to mechanical-thermal complex activated recycled fine powder. The moisture susceptibility deterioration of asphalt mixture is closely related to processing method and dosage of recycled concrete powder. The moisture susceptibility of asphalt mixture with over 25% recycled concrete powder is obviously attenuated. The stripping amount of immersion rutting test of asphalt mixture with recycled concrete powder is relatively good correlation with rut depth and stripping inflection point in Hamburg wheel tracking test. The immersion rutting test can be used to evaluate the long-term moisture susceptibility of asphalt mixture with recycled concrete powder. The moisture susceptibility, high and low temperature performance of asphalt mixture with recycled concrete powder is improved by addition of fiber, silane coupling agent and aluminium-zirconium coupling agent. The moisture susceptibility of asphalt mixture with recycled concrete powder treated with coupling agent is significantly improved, but it is lower than moisture susceptibility of asphalt mixture with limestone mineral powder. The achievement of this paper will provide the technical reference for resource utilization of recycled concrete powder applied into asphalt pavement.</p>