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<p>Research has demonstrated that psychedelic-assisted therapy (PAT) can reduce anxiety, depression, and demoralization in patients with life-threatening illness. Although PAT routinely produces experiences that are spiritually or existentially meaningful, psychotherapeutic modalities that address spiritual, existential, religious, and theological (SERT) concerns remain underexplored in PAT. In this article, we introduce a novel, manualized approach to psychosocial support in PAT, Meaning and Purpose Therapy Modified for Psilocybin (P-MaP), which was adapted from the original Meaning and Purpose therapy for a multicenter clinical trial for demoralized adults near the end of life. Through the discussion of an amalgamated clinical vignette derived from experiences in this trial, we explore how principles of professional spiritual care can expand and advance psychosocial support in PAT for patients with serious and life-threatening medical illness.</p>

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Meaning and Purpose Therapy Modified for Psilocybin (P-MaP): A Treatment Model for Palliative Care Patients

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Philip S. Garrity,
  • Alicia Danforth,
  • Brian Anderson,
  • Jason M. Thompson

摘要

Research has demonstrated that psychedelic-assisted therapy (PAT) can reduce anxiety, depression, and demoralization in patients with life-threatening illness. Although PAT routinely produces experiences that are spiritually or existentially meaningful, psychotherapeutic modalities that address spiritual, existential, religious, and theological (SERT) concerns remain underexplored in PAT. In this article, we introduce a novel, manualized approach to psychosocial support in PAT, Meaning and Purpose Therapy Modified for Psilocybin (P-MaP), which was adapted from the original Meaning and Purpose therapy for a multicenter clinical trial for demoralized adults near the end of life. Through the discussion of an amalgamated clinical vignette derived from experiences in this trial, we explore how principles of professional spiritual care can expand and advance psychosocial support in PAT for patients with serious and life-threatening medical illness.