<p>This paper presents a new design of a flexible Multiple-Input and Multiple-Output (MIMO) antenna for 5G and Internet of Medical Things (IoMT) applications in healthcare. It evaluates the antenna’s performance and emphasizes its role in connected medical systems. The antenna design employs a flexible substrate that adapts to varying environmental conditions and device geometries, which improves its adaptability and robustness in Internet of Things (IoT) deployments. Experimental validation through simulations and measurements demonstrates that the developed antenna has a stable performance in different configurations such as curved substrates. The simulations and measurements, such as the envelope correlation coefficient, diversity gain, and the total active reflection coefficient, highlight the ability of the antenna to provide reliable connectivity in dynamic IoT environments. Additionally, electromagnetic field simulations of flexible MIMO antenna technologies with a human body model prove that the exposure levels comply with the international safety standards and meet the stringent requirements of modern IoT networks, particularly in healthcare applications.</p>