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<p>The accurate detection of vital biomarkers such as Ascorbic Acid (AA), Uric Acid (UA) and Nitrite (NO<sub>2</sub><sup>−</sup>) is crucial for human health surveillance. However, existing methods often struggle with concurrent detection and quantification of multiple species, highlighting the need for a more effective solution. To address this challenge, this study aimed to develop a multifunctional electrochemical sensor capable of parallel detection of AA, UA and NO<sub>2</sub><sup>−</sup> using a synergistic combination of Graphene Oxide (GO) and Cadmium Sulfide (CdS) materials. Notably, the fabricated CdS@GO/Glassy Carbon Electrode (GCE) exhibited exceptional electrochemical activity, as evidenced by Differential Pulse Voltammetry (DPV) analysis. The sensor demonstrated remarkable sensitivity (8.13, 10.12, and 9.05 μA·μM<sup>−1</sup>·cm<sup>−2</sup>) and ultra-low detection limits (0.034, 0.062, and 0.084&#xa0;µM) for AA, UA and NO<sub>2</sub><sup>−</sup>, respectively. Furthermore, it successfully identified single molecules of each analyte in aqueous and biologic fluid samples, with recovery values comparable to those obtained using High-Performance Liquid Chromatography (HPLC) standard addition methods. The significance of this study lies in developing a novel CdS@GO/GCE sensor that enables concurrent detection and quantification of multiple vital biomarkers, offering a promising tool for human health monitoring and diagnosis.</p>

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Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

  • 期刊论文

  • 发表日期：

    2025年1月23日

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  • A. Dhamodharan,
  • E. Murugan,
  • Huan Pang,
  • K. Perumal,
  • K. Jhansirani,
  • Yajun Gao

摘要

The accurate detection of vital biomarkers such as Ascorbic Acid (AA), Uric Acid (UA) and Nitrite (NO2−) is crucial for human health surveillance. However, existing methods often struggle with concurrent detection and quantification of multiple species, highlighting the need for a more effective solution. To address this challenge, this study aimed to develop a multifunctional electrochemical sensor capable of parallel detection of AA, UA and NO2− using a synergistic combination of Graphene Oxide (GO) and Cadmium Sulfide (CdS) materials. Notably, the fabricated CdS@GO/Glassy Carbon Electrode (GCE) exhibited exceptional electrochemical activity, as evidenced by Differential Pulse Voltammetry (DPV) analysis. The sensor demonstrated remarkable sensitivity (8.13, 10.12, and 9.05 μA·μM−1·cm−2) and ultra-low detection limits (0.034, 0.062, and 0.084 µM) for AA, UA and NO2−, respectively. Furthermore, it successfully identified single molecules of each analyte in aqueous and biologic fluid samples, with recovery values comparable to those obtained using High-Performance Liquid Chromatography (HPLC) standard addition methods. The significance of this study lies in developing a novel CdS@GO/GCE sensor that enables concurrent detection and quantification of multiple vital biomarkers, offering a promising tool for human health monitoring and diagnosis.