<p>Widening social and environmental inequities in the United States and globally disproportionately impact marginalized and oppressed populations, many of whom are perceived—and perceive themselves—as lacking power to effect change. Yet, substantial evidence has demonstrated the potential of nonviolent and constructive resistance strategies to produce transformative outcomes. Research has also shown the success of smaller-scale, localized civil resistance efforts. This article examines how behavior scientists and community organizers can leverage the complementary strengths of culturo-behavioral systems science and constructive noncooperation to disrupt oppressive systems while cultivating new social, cultural, and political arrangements rooted in justice. Drawing on historical and contemporary cases, including Gandhian constructive programs, labor movements, and community organizing efforts, we illustrate how matrix analyses and systems perspectives can guide the development of effective strategies. Ultimately, constructive programs represent a strategic imperative for initiating and sustaining systemic change by enabling communities to withdraw support from oppressive structures, construct viable alternatives, and reconfigure networks of power in ways that promote equity, dignity, and human well-being.</p>