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<p>The monophasic <i>Salmonella</i> Typhimurium variant (1,4,[5],12:i:-) is a growing global public health and food safety concern. This study analyzed 60 such isolates collected in Huzhou (2023–2025), including 16 outbreak strains. All isolates belonged to ST34 and carried 211 virulence genes. Antimicrobial susceptibility testing showed universal resistance to tetracycline (100%) and a high multidrug resistance rate (96.67% resistant to ≥ 3 antibiotic classes). Whole-genome sequencing identified 39 resistance genes; aac(6´)-Iaa was present in all strains, and 48.33% carried ≥ 4 resistance genes. Phylogenetic analysis revealed high overall homology with localized evolutionary traits. Notably, clinical outbreak and food-derived isolates were clonally identical (0 SNP difference).</p>

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Outbreak of multidrug-resistant Salmonella typhimurium monophasic variant 1,4,[5],12:i:- sequence type 34 linked to food, in China

  • 期刊论文

  • 发表日期：

    2026年7月6日

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  • Wei Yan,
  • Deshun Xu,
  • Peng Zhang,
  • Liping Chen,
  • Xiaofang Wu

摘要

The monophasic Salmonella Typhimurium variant (1,4,[5],12:i:-) is a growing global public health and food safety concern. This study analyzed 60 such isolates collected in Huzhou (2023–2025), including 16 outbreak strains. All isolates belonged to ST34 and carried 211 virulence genes. Antimicrobial susceptibility testing showed universal resistance to tetracycline (100%) and a high multidrug resistance rate (96.67% resistant to ≥ 3 antibiotic classes). Whole-genome sequencing identified 39 resistance genes; aac(6´)-Iaa was present in all strains, and 48.33% carried ≥ 4 resistance genes. Phylogenetic analysis revealed high overall homology with localized evolutionary traits. Notably, clinical outbreak and food-derived isolates were clonally identical (0 SNP difference).