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<p>We conducted genomic analysis of a&#xa0;Chinese beef-derived,&#xa0;<i>mcr</i>-<i>1</i>-positive, multidrug-resistant&#xa0;monophasic<i> Salmonella enterica</i>&#xa0;serovar Typhimurium isolate. Antimicrobial resistance determinants were located on both its chromosome and plasmid.&#xa0;The multidrug resistance was primarily mediated by a novel IncHI2-IncHI2A plasmid harboring 18 resistance genes, including <i>mcr</i>-<i>1</i>,&#xa0;in contrast to only five resistance genes and one resistance-associated mutation detected on the chromosome.&#xa0;These findings underscore the need for enhanced surveillance of this pathogen. </p>

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Genomic analysis of a multidrug-resistant monophasic Salmonella Typhimurium from Chinese beef harboring a novel mcr-1-bearing IncHI2-IncHI2A plasmid

  • 期刊论文

  • 发表日期：

    2026年2月4日

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  • Xiaojuan Yang,
  • Zekun Liu,
  • Shixuan Huang,
  • Shuzhen Cai,
  • Ying Li,
  • Liang Xue,
  • Jumei Zhang,
  • Qingping Wu

摘要

We conducted genomic analysis of a Chinese beef-derived, mcr-1-positive, multidrug-resistant monophasic Salmonella enterica serovar Typhimurium isolate. Antimicrobial resistance determinants were located on both its chromosome and plasmid. The multidrug resistance was primarily mediated by a novel IncHI2-IncHI2A plasmid harboring 18 resistance genes, including mcr-1, in contrast to only five resistance genes and one resistance-associated mutation detected on the chromosome. These findings underscore the need for enhanced surveillance of this pathogen.