Scholarlink

<p>Infected bone defects arising from trauma or tumour resection pose significant challenges in orthopaedic reconstruction. To address these challenges, silver nanorods (AgNRs) were encapsulated within Sr-doped mesoporous bioactive glass (BG@Sr) and incorporated into polylactic acid (PLA)/ gelatine fibres via a ‘one-pot’ electrospinning technique to prepare artificial periosteum (PAR-Sr), which enables photothermally triggered antibacterial Ag⁺ release and sustained osteogenic Sr<sup>2</sup>⁺ delivery. Sr doping-generated negatively charged Si–O⁻ and nonbridging oxygen (NBO) species effectively modulate Ag⁺ release kinetics to prevent burst effects. PAR-Sr periosteum replicates the mechanical profile of the native human periosteum, while retaining critical flexibility, lightweight properties, and physiological stretchability. In vitro studies confirmed that PAR-Sr achieved a photothermal conversion efficiency of 33.8% and demonstrated significant antibacterial efficacy against both planktonic and biofilm forms (&gt; 99%) under near infrared (NIR) irradiation. Furthermore, PAR-Sr demonstrates exceptional biocompatibility and osteogenic potential, as evidenced by its ability to upregulate osteogenic-related gene expression, increase alkaline phosphatase (ALP) activity, and promote extracellular matrix (ECM) mineralization. In a rat cranial defect infection model, the PAR-Sr periosteum exhibited remarkable osseointegration capacity under NIR irradiation, while simultaneously reducing postoperative inflammatory responses. This periosteum represents a promising therapeutic strategy for preventing implant-associated infections and enhancing bone integration in orthopaedic applications.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Artificial Periosteum with Balanced Antibacterial and Osteogenic Properties Regulated by NIR Radiation and Strontium Doping

  • 期刊论文

  • 发表日期：

    2025年12月18日

查看全文
  • Yuhan Zhang,
  • Lechun Deng,
  • Jingjie Yu,
  • Lehao Han,
  • Xiaodan Jiang,
  • Jiale Yang,
  • Junzi Han,
  • Hongjing Wu,
  • Yinbo Niu,
  • Qiang Chen

摘要

Infected bone defects arising from trauma or tumour resection pose significant challenges in orthopaedic reconstruction. To address these challenges, silver nanorods (AgNRs) were encapsulated within Sr-doped mesoporous bioactive glass (BG@Sr) and incorporated into polylactic acid (PLA)/ gelatine fibres via a ‘one-pot’ electrospinning technique to prepare artificial periosteum (PAR-Sr), which enables photothermally triggered antibacterial Ag⁺ release and sustained osteogenic Sr2⁺ delivery. Sr doping-generated negatively charged Si–O⁻ and nonbridging oxygen (NBO) species effectively modulate Ag⁺ release kinetics to prevent burst effects. PAR-Sr periosteum replicates the mechanical profile of the native human periosteum, while retaining critical flexibility, lightweight properties, and physiological stretchability. In vitro studies confirmed that PAR-Sr achieved a photothermal conversion efficiency of 33.8% and demonstrated significant antibacterial efficacy against both planktonic and biofilm forms (> 99%) under near infrared (NIR) irradiation. Furthermore, PAR-Sr demonstrates exceptional biocompatibility and osteogenic potential, as evidenced by its ability to upregulate osteogenic-related gene expression, increase alkaline phosphatase (ALP) activity, and promote extracellular matrix (ECM) mineralization. In a rat cranial defect infection model, the PAR-Sr periosteum exhibited remarkable osseointegration capacity under NIR irradiation, while simultaneously reducing postoperative inflammatory responses. This periosteum represents a promising therapeutic strategy for preventing implant-associated infections and enhancing bone integration in orthopaedic applications.

Graphical Abstract