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<p>Epigenetic signatures, particularly DNA methylation, have emerged as potential biomarkers in various cancers, including adult B-ALL. In particular, DNA methylation increases with age and significantly affects overall survival. As a result, it holds promise as a diagnostic tool for B-ALL, providing insights into disease progression and prognosis. By integrating epigenetic and transcriptomic analyses, we identified potential biomarkers associated with B-ALL. Notably, our findings suggest that the methylation status of brain abundant membrane attached signal protein 1 (BASP1) is linked to relapse in B-ALL and may serve as a valuable diagnostic marker.</p>

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BASP1 is a potential relapse-associated diagnostic marker for adult patients with B-cell acute lymphoblastic leukemia

  • 期刊论文

  • 发表日期：

    2025年3月10日

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  • Haiyu Song,
  • Ruiqi Wang,
  • Weijie Liao,
  • Li Yu

摘要

Epigenetic signatures, particularly DNA methylation, have emerged as potential biomarkers in various cancers, including adult B-ALL. In particular, DNA methylation increases with age and significantly affects overall survival. As a result, it holds promise as a diagnostic tool for B-ALL, providing insights into disease progression and prognosis. By integrating epigenetic and transcriptomic analyses, we identified potential biomarkers associated with B-ALL. Notably, our findings suggest that the methylation status of brain abundant membrane attached signal protein 1 (BASP1) is linked to relapse in B-ALL and may serve as a valuable diagnostic marker.