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<p>The larvae of <i>Lucilia sericata</i> play a pivotal role in maggot debridement therapy, an established method for wound management that is now recognized for its efficacy in treating chronic wounds. The excretion/secretions (ES) of larvae are rich in various bioactive compounds that facilitate disinfection, debridement, and enhancement of wound healing processes. During wound healing treatment with larvae, the volatile compounds of primary and secondary metabolites secreted by the larvae are extensively exposed to the wound area. To characterize the volatile components of secretion, larvae were obtained from the fly insectary, followed by extraction using saline solution and subsequent SPME-GC/MS analysis. Subsequently, the pharmacological effects of secretion were evaluated in silico. 1-Pentanol and beta-ionone epoxide components, which constitute the majority of the secretion have high antimicrobial activity against <i>Staphylococcus aureus</i> and <i>Candida albicans</i> species as well as low carcinogenicity and skin permeability. As a result of PASS analysis from the obtained data highlight the potential of the volatile components of the larval secretion in the treatment of different dermatological diseases such as psoriasis, melanoma, and acne.</p>

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SPME-GC-MS profiling of volatile compounds in Lucilia sericata larva extract and in Silico biotherapeutic analysis

  • 期刊论文

  • 发表日期：

    2025年3月25日

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  • Hatice Tosyagülü Çelik,
  • Nilüfer Vural,
  • Sibel Kaymak

摘要

The larvae of Lucilia sericata play a pivotal role in maggot debridement therapy, an established method for wound management that is now recognized for its efficacy in treating chronic wounds. The excretion/secretions (ES) of larvae are rich in various bioactive compounds that facilitate disinfection, debridement, and enhancement of wound healing processes. During wound healing treatment with larvae, the volatile compounds of primary and secondary metabolites secreted by the larvae are extensively exposed to the wound area. To characterize the volatile components of secretion, larvae were obtained from the fly insectary, followed by extraction using saline solution and subsequent SPME-GC/MS analysis. Subsequently, the pharmacological effects of secretion were evaluated in silico. 1-Pentanol and beta-ionone epoxide components, which constitute the majority of the secretion have high antimicrobial activity against Staphylococcus aureus and Candida albicans species as well as low carcinogenicity and skin permeability. As a result of PASS analysis from the obtained data highlight the potential of the volatile components of the larval secretion in the treatment of different dermatological diseases such as psoriasis, melanoma, and acne.