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<p><i>Costus speciosus</i> is a plant used in traditional medicine. It is widely used as a treatment for diabetes in Sri Lanka, India and neighboring countries. An endophytic fungus, <i>Edenia gomezpompae,</i> isolated from the leaves of <i>Costus speciosus,</i> was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of rare compounds leptosphaeridione (1) and preussomerin EG<sub>2</sub> (2). This is the first report of the isolation of the endophytic fungus <i>E. gomezpompae</i> from <i>C. speciosus</i>. Both compounds were screened for their enzyme inhibitory activity toward α-glucosidase, α-amylase, lipase and acetylcholinesterase. Compounds 1 and 2 exhibited significant α-glucosidase inhibitory activity with the IC<sub>50</sub> values of 2.39&#xa0;μg/mL and 27.9&#xa0;μg/mL, respectively. This study contributes to our knowledge on the diversity and chemical potential of fungal endophytes associated with medicinal plants.</p>

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α-Glucosidase inhibitors from an endophytic fungus Edenia gomezpompae from Costus speciosus

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • B. M. S. Nilmini,
  • Kavindya Samarakoon,
  • Deepthi Yakandawala,
  • Savitri Kumar,
  • Nimal Adikaram,
  • Lalith Jayasinghe,
  • Hiroshi Araya,
  • Yoshinori Fujimoto

摘要

Costus speciosus is a plant used in traditional medicine. It is widely used as a treatment for diabetes in Sri Lanka, India and neighboring countries. An endophytic fungus, Edenia gomezpompae, isolated from the leaves of Costus speciosus, was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of rare compounds leptosphaeridione (1) and preussomerin EG2 (2). This is the first report of the isolation of the endophytic fungus E. gomezpompae from C. speciosus. Both compounds were screened for their enzyme inhibitory activity toward α-glucosidase, α-amylase, lipase and acetylcholinesterase. Compounds 1 and 2 exhibited significant α-glucosidase inhibitory activity with the IC50 values of 2.39 μg/mL and 27.9 μg/mL, respectively. This study contributes to our knowledge on the diversity and chemical potential of fungal endophytes associated with medicinal plants.