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<p>Medicinal plants offer promising alternatives for combating infectious diseases, particularly those caused by antibiotic-resistant bacteria. This study aims to identify and evaluate the chemical composition and antibacterial activity of hexane and ethanol extracts from four medicinal plants: red ginger rhizome (<i>Zingiber officinale</i>), moringa leaves (<i>Moringa oleifera</i>), green betel leaves (<i>Piper betle</i>), and butterfly pea flowers (<i>Clitoria ternatea</i>). The chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS), while antibacterial activity was assessed against <i>Salmonella typhi</i> and <i>Escherichia coli.</i> GC-MS analysis revealed distinct chemical profiles between hexane and ethanol extracts. Antibacterial assays showed that only green betel leaf extracts exhibited inhibition, with the ethanol extract demonstrating the highest activity against <i>Salmonella typhi</i> (32.5 ± 2.12&#xa0;mm) and <i>Escherichia coli</i> (28.5 ± 0.71&#xa0;mm). In contrast, extracts from red ginger, moringa (hexane extract), and butterfly pea showed no antibacterial effects. These findings highlight the potential of <i>Piper betle</i>, particularly its ethanol extract, as a natural antibacterial agent and warrant further investigation into its bioactive compounds.</p>

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Identification and evaluation of bioactive compound from selected medicinal plants: potential antibacterial agent

  • 期刊论文

  • 发表日期：

    2025年8月6日

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  • Rita Noveriza,
  • Efriwati,
  • Melati,
  • Sitti Fatimah Syahid

摘要

Medicinal plants offer promising alternatives for combating infectious diseases, particularly those caused by antibiotic-resistant bacteria. This study aims to identify and evaluate the chemical composition and antibacterial activity of hexane and ethanol extracts from four medicinal plants: red ginger rhizome (Zingiber officinale), moringa leaves (Moringa oleifera), green betel leaves (Piper betle), and butterfly pea flowers (Clitoria ternatea). The chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS), while antibacterial activity was assessed against Salmonella typhi and Escherichia coli. GC-MS analysis revealed distinct chemical profiles between hexane and ethanol extracts. Antibacterial assays showed that only green betel leaf extracts exhibited inhibition, with the ethanol extract demonstrating the highest activity against Salmonella typhi (32.5 ± 2.12 mm) and Escherichia coli (28.5 ± 0.71 mm). In contrast, extracts from red ginger, moringa (hexane extract), and butterfly pea showed no antibacterial effects. These findings highlight the potential of Piper betle, particularly its ethanol extract, as a natural antibacterial agent and warrant further investigation into its bioactive compounds.