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<p><i>Adenia lobata</i> (Passifloracae) is a climbing plant useful as trado-medicine for treating cough, syphilis, hemorrhoids, nasal cancer, and gonorrhea. This research aimed at isolating essential oils (EOs) from the fresh and air-dried leaf and stalk of <i>Adenia lobata</i> and then investigating their potential bioactivities. EOs were extracted from <i>A. lobata</i> using a Clevenger-type apparatus. Antibacterial activities were tested using the disc diffusion method against five bacterial strains: <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Bacillus subtilis</i>, <i>Salmonella typhi</i>, and <i>Klebsiella oxytoca</i>. Antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method while the cytotoxicity assay was done using brine shrimps. In the fresh and air-dried leaf and stalk EOs, thirty-one compounds were identified by Gas Chromatography–Mass Spectrometry. Phytol was the most abundant component of the fresh leaf (83.81%) and fresh stalk (34.85%), while (8E)-10-Methyl-8-tetradecenyl-acetate (21.04%) and p-Xylene (51.32%) were respectively the most abundant in the air-dried leaf and air-dried stalk EOs. Fresh leaves EO had the highest bacterial inhibition and it was against <i>Staphylococcus aureus</i> (14&#xa0;mm). The antioxidant values ranged from IC<sub>50</sub> 226.5–2097.1&#xa0;µg/mL with the fresh stalk EO being the most active antioxidant. Cytotoxicity assay using <i>Artemia nauplii</i> yielded promising activities (LC<sub>50</sub> = 7.86 × 10<sup>− 11</sup> − 1.43&#xa0;µg/mL) compared with vincristine (LC<sub>50</sub> = 0.95&#xa0;µg/mL). The air-dried leaves showed the highest cytotoxicity while the lowest activity was observed for air-dried stalk EO. The results observed for these bioassays suggest that the EOs from this plant have potential as an antibacterial, antioxidant, and cytotoxic agent.</p>

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Essential oils of Adenia lobata (Jacq.) Engl. have potential antibacterial, antioxidant and cytotoxicity activities

  • 期刊论文

  • 发表日期：

    2025年6月10日

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  • Eniola O. Anifalaje,
  • Sunday K. Ogundairo,
  • Olapeju O. Aiyelaagbe,
  • Olusegun Ekundayo

摘要

Adenia lobata (Passifloracae) is a climbing plant useful as trado-medicine for treating cough, syphilis, hemorrhoids, nasal cancer, and gonorrhea. This research aimed at isolating essential oils (EOs) from the fresh and air-dried leaf and stalk of Adenia lobata and then investigating their potential bioactivities. EOs were extracted from A. lobata using a Clevenger-type apparatus. Antibacterial activities were tested using the disc diffusion method against five bacterial strains: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Klebsiella oxytoca. Antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method while the cytotoxicity assay was done using brine shrimps. In the fresh and air-dried leaf and stalk EOs, thirty-one compounds were identified by Gas Chromatography–Mass Spectrometry. Phytol was the most abundant component of the fresh leaf (83.81%) and fresh stalk (34.85%), while (8E)-10-Methyl-8-tetradecenyl-acetate (21.04%) and p-Xylene (51.32%) were respectively the most abundant in the air-dried leaf and air-dried stalk EOs. Fresh leaves EO had the highest bacterial inhibition and it was against Staphylococcus aureus (14 mm). The antioxidant values ranged from IC50 226.5–2097.1 µg/mL with the fresh stalk EO being the most active antioxidant. Cytotoxicity assay using Artemia nauplii yielded promising activities (LC50 = 7.86 × 10− 11 − 1.43 µg/mL) compared with vincristine (LC50 = 0.95 µg/mL). The air-dried leaves showed the highest cytotoxicity while the lowest activity was observed for air-dried stalk EO. The results observed for these bioassays suggest that the EOs from this plant have potential as an antibacterial, antioxidant, and cytotoxic agent.