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<p>People have been using herbal remedies since long before they started writing things down. <i>Dendrocnide sinuata</i> (Blume), a tree belonging to the Urticaceae family, has been traditionally employed as a supplementary medication to alleviate various disorders. The goal of this study was to assess the antioxidant potential and potential bioactive ingredients in the ethanolic extract of <i>Dendrocnide sinuata</i> (Blume) leaves. Phytochemical screening of ethanolic extract of <i>Dendrocnide sinuata</i> (Blume) leaf revealed the presence of alkaloids, saponins, flavonoids, phenols, tannins, steroids and terpenoids. The GC–MS analysis revealed the presence of twenty-one bioactive compounds. The biologically active compounds demonstrated significant potency in <i>In-silico</i> molecular docking studies. Additionally, ADME analysis revealed that these compounds possess promising pharmacokinetic properties and favorable drug-likeness characteristics, supporting their potential as viable candidates for drug development. The leaf extract of <i>Dendrocnide sinuata</i> has been scrutinized for its antioxidant content, indicating its potential as a natural source of antioxidants for pharmaceutical applications and animal nutrition due to its free radical scavenging capabilities.</p>

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Integrative analysis of Dendrocnide sinuata leaf extract: chemical composition and antioxidant activity via spectroscopic and computational methods

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Jyutia Nargish,
  • Siddhartha Sankar Das,
  • Bhaswati Kashyap,
  • Rosy Ahmed,
  • Himsikhar Sarma,
  • Nilutpal Sharma Bora,
  • Sameeran Gam,
  • Kangkan Deka,
  • Bitu Gogoi,
  • Muslek Uddin Mazumder,
  • Koushik Nandan Dutta

摘要

People have been using herbal remedies since long before they started writing things down. Dendrocnide sinuata (Blume), a tree belonging to the Urticaceae family, has been traditionally employed as a supplementary medication to alleviate various disorders. The goal of this study was to assess the antioxidant potential and potential bioactive ingredients in the ethanolic extract of Dendrocnide sinuata (Blume) leaves. Phytochemical screening of ethanolic extract of Dendrocnide sinuata (Blume) leaf revealed the presence of alkaloids, saponins, flavonoids, phenols, tannins, steroids and terpenoids. The GC–MS analysis revealed the presence of twenty-one bioactive compounds. The biologically active compounds demonstrated significant potency in In-silico molecular docking studies. Additionally, ADME analysis revealed that these compounds possess promising pharmacokinetic properties and favorable drug-likeness characteristics, supporting their potential as viable candidates for drug development. The leaf extract of Dendrocnide sinuata has been scrutinized for its antioxidant content, indicating its potential as a natural source of antioxidants for pharmaceutical applications and animal nutrition due to its free radical scavenging capabilities.