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<p>Nine compounds from the fermentation of <i>Diaporthe melonis</i>, an endophytic fungus in the inflorescence of <i>Acalypha indica</i> L. (Euphorbiaceae), were isolated and identified. They are 1,8-dimethoxynaphthalene (<b>1</b>), 8-methoxynaphthalen-1-ol (<b>2</b>), 4-hydroxybenzoic acid (<b>3</b>), 1-(2,6-dihydroxyphenyl)butanone (<b>4</b>), methyl (4-hydroxyphenyl)acetate (<b>5</b>), 3-nitropropanoic acid (<b>6</b>), phomonitroester (<b>7</b>), felinone A (<b>8</b>) and (4<i>R</i>,6<i>R</i>)-4-hydroxy-6-methyltetrahydro-2<i>H</i>-pyran-2-one (<b>9</b>). The EtOAc crude extract resulted in strong cytotoxicity, radicle elongation inhibition and a strong potential to inhibit α-glucosidase enzyme. This is the first report of the strong α-glucosidase and strong phytotoxicity of compound <b>4</b>.</p> Graphical abstract <p></p>

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α-Glucosidase inhibitor and phytotoxic metabolite produced by an endophytic fungus Diaporthe melonis isolated from Acalypha indica L

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Jayani Kalinga,
  • Kavindya Samarakoon,
  • Upesha Siriwardhane,
  • Deepthi Yakandawala,
  • Nimal Adikaram,
  • Lalith Jayasinghe,
  • Hiroshi Araya,
  • Yoshinori Fujimoto

摘要

Nine compounds from the fermentation of Diaporthe melonis, an endophytic fungus in the inflorescence of Acalypha indica L. (Euphorbiaceae), were isolated and identified. They are 1,8-dimethoxynaphthalene (1), 8-methoxynaphthalen-1-ol (2), 4-hydroxybenzoic acid (3), 1-(2,6-dihydroxyphenyl)butanone (4), methyl (4-hydroxyphenyl)acetate (5), 3-nitropropanoic acid (6), phomonitroester (7), felinone A (8) and (4R,6R)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-one (9). The EtOAc crude extract resulted in strong cytotoxicity, radicle elongation inhibition and a strong potential to inhibit α-glucosidase enzyme. This is the first report of the strong α-glucosidase and strong phytotoxicity of compound 4.

Graphical abstract