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<p>Herbal medicines are widely utilized across different regions of the world for the treatment of various diseases. Plant-derived compounds represent a promising strategy in the fight against bacterial resistance, particularly in multidrug-resistant strains. This study aimed to evaluate the antibacterial activity of hydroethanolic extract of <i>Luetzelburgia auriculata</i> leaves against multidrug-resistant strains of <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, both in terms of direct antibacterial effects and potential adjuvant activity. The chemical composition of the extract was assessed through qualitative phytochemical analysis, while antibacterial activity was evaluated using broth microdilution method. Phytochemical screening revealed the presence of flavones, flavonoids, leucoanthocyanidins, catechins, and alkaloids. Although the extract did not exhibit direct antibacterial activity against tested strains, it was able to modulate bacterial resistance mechanisms against gentamicin and ciprofloxacin. A potential mechanism of action suggested in this study is the interference with bacterial efflux pumps, which play a crucial role in antimicrobial resistance.</p>

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Potentiating-antibiotic and antibacterial properties of Luetzelburgia auriculata (ALLEMÃO) Ducke against MDR bacterial strains

  • 期刊论文

  • 发表日期：

    2025年3月11日

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  • Thiago S. Freitas,
  • Janaina E. Rocha,
  • Marcos J. F. Lima,
  • Carla F. A. Nonato,
  • Cicera J. Camilo,
  • Cicera L. R. Paulo,
  • Maria A. S. Alencar,
  • Isaac M. Araújo,
  • Karla S. T. G. Belém,
  • Selvina P. Silva,
  • Francisco N. Pereira Junior,
  • Hélcio S. Santos,
  • Jane E. S. A. Menezes,
  • Alexandre M. R. Teixeira,
  • Henrique D. M. Coutinho

摘要

Herbal medicines are widely utilized across different regions of the world for the treatment of various diseases. Plant-derived compounds represent a promising strategy in the fight against bacterial resistance, particularly in multidrug-resistant strains. This study aimed to evaluate the antibacterial activity of hydroethanolic extract of Luetzelburgia auriculata leaves against multidrug-resistant strains of Staphylococcus aureus and Escherichia coli, both in terms of direct antibacterial effects and potential adjuvant activity. The chemical composition of the extract was assessed through qualitative phytochemical analysis, while antibacterial activity was evaluated using broth microdilution method. Phytochemical screening revealed the presence of flavones, flavonoids, leucoanthocyanidins, catechins, and alkaloids. Although the extract did not exhibit direct antibacterial activity against tested strains, it was able to modulate bacterial resistance mechanisms against gentamicin and ciprofloxacin. A potential mechanism of action suggested in this study is the interference with bacterial efflux pumps, which play a crucial role in antimicrobial resistance.