<p>The Corvis ST (Oculus, Germany) has emerged as a leading non-contact device for in vivo assessment of corneal biomechanics, combining ultra-high-speed Scheimpflug imaging with a precisely controlled air-puff to capture dynamic corneal deformation. This review provides a comprehensive overview of its principles, measurement capabilities, and clinical applications. We discuss primary parameters that are directly measured from corneal deformation responses and secondary indices that are derived through computational modeling, such as the biomechanically corrected intraocular pressure (bIOP), the Stress–Strain Index (SSI), the Corvis Biomechanical Index (CBI), and the Tomographic and Biomechanical Index (TBI). To enhance clarity, we also summarize the key parameters that contribute to these indices, helping readers understand their components more intuitively, rather than relying on trial and error when comparing them with other biomechanical factors. These indices have significantly advanced the diagnosis of keratoconus, risk stratification in refractive surgery, glaucoma management, and evaluation of cross-linking outcomes. However, important challenges remain, including variability across populations and devices, the confounding effects of intraocular pressure and hydration, and reduced reliability in pediatric or post-surgical corneas. Emerging approaches—such as finite element modeling, artificial intelligence (AI)-driven classification, modal analysis, and multimodal imaging integration—offer promising pathways to overcome these limitations. Ultimately, the Corvis ST serves not only as a critical clinical tool but also as a foundation for next-generation digital ophthalmology, supporting more precise, personalized, and predictive care.</p>