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<p>Delivery of an infant before the completion of 37&#xa0;weeks of gestation is considered preterm birth (PTB). Admission of preterm infants to the neonatal intensive care unit (NICU) causes considerable stress that impedes their growth. A recent innovation in the neonatal care is the Mother Newborn Care Unit (MNCU), which is a facility where sick and small newborns are cared with their mothers 24 × 7 with all facilities of sick newborn care and provision for postnatal care to mothers. This study includes preterm babies (birth weight 1 to 1.8&#xa0;kg) admitted to either MNCU or NICU. We collected saliva from these babies at admission and discharge and measured cortisol levels in these samples as an indicator of stress. Based on protein quantitation, we chose 12 pairs of salivary samples for MS-based proteomics and quantified 308 protein groups. Differential protein analysis of MNCU vs NICU revealed 44 and 41 differentially expressed proteins (DEPs) and in pathway enrichment of unique DEPs, 22 and 19 proteins were present in the admission and discharge group, respectively. We report protein changes involved in immune and metabolic pathways with important functions. Thus, our study shows evidence in favor of MNCU care that enhance the growth and lower the preterm stress.</p> Graphical abstract <p></p>

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Salivary proteome profiling to assess the impact of zero separation in Mother Newborn Care Unit on neonatal growth and stress

  • 期刊论文

  • 发表日期：

    2025年3月29日

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  • Leena Kaushik,
  • Kiran Nehra,
  • Naman Kharbanda,
  • Sandhini Saha,
  • Nitya Wadhwa,
  • Pratima Anand,
  • Sugandha Arya,
  • Harish Chellani,
  • Tushar Kanti Maiti

摘要

Delivery of an infant before the completion of 37 weeks of gestation is considered preterm birth (PTB). Admission of preterm infants to the neonatal intensive care unit (NICU) causes considerable stress that impedes their growth. A recent innovation in the neonatal care is the Mother Newborn Care Unit (MNCU), which is a facility where sick and small newborns are cared with their mothers 24 × 7 with all facilities of sick newborn care and provision for postnatal care to mothers. This study includes preterm babies (birth weight 1 to 1.8 kg) admitted to either MNCU or NICU. We collected saliva from these babies at admission and discharge and measured cortisol levels in these samples as an indicator of stress. Based on protein quantitation, we chose 12 pairs of salivary samples for MS-based proteomics and quantified 308 protein groups. Differential protein analysis of MNCU vs NICU revealed 44 and 41 differentially expressed proteins (DEPs) and in pathway enrichment of unique DEPs, 22 and 19 proteins were present in the admission and discharge group, respectively. We report protein changes involved in immune and metabolic pathways with important functions. Thus, our study shows evidence in favor of MNCU care that enhance the growth and lower the preterm stress.

Graphical abstract