<p>CO₂ nanobubble existed at dolomite mineral surface under acidic conditions and has significant impact in the flotation of dolomite. In this regard, the impact of the CO₂ molecule on the adsorption and wettability of dolomite in deionized water as a function of pH was investigated by atomic force microscope (AFM), contact angle, bubble-particle attachment, micro-flotation, and molecular dynamics simulations. The dissolution of dolomite under acidic conditions resulted in the formation of CO₂ nanobubbles, which achieved higher contact angle, adhesion work, and flotation efficiency of dolomite. The simulated contact angle is in accord with experimental result, and the surface water molecule density of dolomite without a CO₂ layer was observed to be higher than that of dolomite with a CO₂ layer. Those findings offer a theoretical and experimental foundation for enhancing the flotation efficiency of dolomite with CO₂ nanobubbles under acidic conditions.</p> Graphical Abstract <p></p>