Scholarlink

<p>Rapid advancement of plant-based nanotechnology, offering a cost-effective, green and sustainable approach for producing biocompatible nanomaterials such as gold nanoparticles, has gained profound interest in biomedical applications, especially in cancer therapy. This review discusses phytosynthesis principles, synthesized nanoparticle characterization, and their reported effectiveness against cancer cells, providing sustainable therapeutic alternatives. Plant extracts provide reducing and stabilizing agents that impact the size, shape and surface properties of nanoparticles, which in turn influence the therapeutic abilities of these nanoparticles. Characterization techniques, including UV-Vis spectroscopy, TEM and SEM-EDX, XRD, FTIR, DLS and zeta potential, confirm the structural, functional and stability potentials of nanoparticles in biomedical applications. Reported in vitro and in vivo studies highlight anticancer mechanisms of photosynthesized gold nanoparticles, such as reactive oxygen species (ROS) generation, apoptosis induction, anti-angiogenesis, and selective cytotoxicity, showing enhanced therapeutic efficiency and minimal systemic toxicity. Phytosynthesized gold nanoparticles not only offer immense potential as biocompatible anticancer agents, but also find applications in diagnostics, biosensing and targeted drug delivery systems. However, challenges such as reproducibility, scalability, pharmacokinetics, toxicity, and process regulations still remain limitations hindering their clinical translation. Addressing these challenges through standardized protocols and regulations, scalable reactors, pharmacokinetic studies, toxicological assessments, and integration of machine learning, allowing for more precise mechanistic insights, will be pivotal for advancing their therapeutic and industrial applications.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phytosynthesis of gold nanoparticles and their potential applications as anticancer agent: a review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月11日

查看全文
  • Cornelius Aboderin,
  • Abel Kolawole Oyebamiji,
  • Florence Yetunde Akinloye,
  • Kehinde Francis Akinloye,
  • Mary O. Kaka,
  • Sunday Adewale Akintelu,
  • Oluwaseun Emmanuel Agboola,
  • Oluwakemi Ebenezer,
  • Emmanuel T. Akintayo,
  • Cecilia O. Akintayo

摘要

Rapid advancement of plant-based nanotechnology, offering a cost-effective, green and sustainable approach for producing biocompatible nanomaterials such as gold nanoparticles, has gained profound interest in biomedical applications, especially in cancer therapy. This review discusses phytosynthesis principles, synthesized nanoparticle characterization, and their reported effectiveness against cancer cells, providing sustainable therapeutic alternatives. Plant extracts provide reducing and stabilizing agents that impact the size, shape and surface properties of nanoparticles, which in turn influence the therapeutic abilities of these nanoparticles. Characterization techniques, including UV-Vis spectroscopy, TEM and SEM-EDX, XRD, FTIR, DLS and zeta potential, confirm the structural, functional and stability potentials of nanoparticles in biomedical applications. Reported in vitro and in vivo studies highlight anticancer mechanisms of photosynthesized gold nanoparticles, such as reactive oxygen species (ROS) generation, apoptosis induction, anti-angiogenesis, and selective cytotoxicity, showing enhanced therapeutic efficiency and minimal systemic toxicity. Phytosynthesized gold nanoparticles not only offer immense potential as biocompatible anticancer agents, but also find applications in diagnostics, biosensing and targeted drug delivery systems. However, challenges such as reproducibility, scalability, pharmacokinetics, toxicity, and process regulations still remain limitations hindering their clinical translation. Addressing these challenges through standardized protocols and regulations, scalable reactors, pharmacokinetic studies, toxicological assessments, and integration of machine learning, allowing for more precise mechanistic insights, will be pivotal for advancing their therapeutic and industrial applications.

Graphical abstract