Scholarlink

<p>The stability and efficacy of pharmaceuticals during long-duration space mion International Space Stationions are critically challenged by unique conditions, such as microgravity, cosmic radiation, and temperature fluctuations. Initially, these environmental factors compromise drug formulation and stability, whereas spaceflight-induced physiological changes alter pharmacokinetics, including absorption, metabolism, and excretion. To address the challenges of long-term space conditions, innovative approaches such as nanotechnology-based drug encapsulation and 3D printing of personalized medicines have been developed, enabling enhanced stability and on-demand production in space. Furthermore, advanced drug delivery systems, including implantable and wearable devices, offer controlled and adaptive therapeutic administration that is suited to microgravity environments. Continued research and collaboration between space agencies and the pharmaceutical industry are essential for developing space-specific pharmaceuticals to ensure astronaut health and isuccess in future deep-space exploration. The objectives of this review are to investigate novel formulation and delivery technologies created to address these difficulties in microgravity settings, clarify the physicochemical and biological processes influencing drug efficacy, and investigate the elements causing pharmaceutical instability in space.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Stability and drug delivery challenges of pharmaceutical formulations in microgravity environments

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月4日

查看全文
  • Nayudu Teja,
  • Veera Venkata Satya Naryana Reddy Karri,
  • Gowthamarajan Kuppusamy,
  • Survo Chatterjee,
  • Vetriselvan Subramaniyan

摘要

The stability and efficacy of pharmaceuticals during long-duration space mion International Space Stationions are critically challenged by unique conditions, such as microgravity, cosmic radiation, and temperature fluctuations. Initially, these environmental factors compromise drug formulation and stability, whereas spaceflight-induced physiological changes alter pharmacokinetics, including absorption, metabolism, and excretion. To address the challenges of long-term space conditions, innovative approaches such as nanotechnology-based drug encapsulation and 3D printing of personalized medicines have been developed, enabling enhanced stability and on-demand production in space. Furthermore, advanced drug delivery systems, including implantable and wearable devices, offer controlled and adaptive therapeutic administration that is suited to microgravity environments. Continued research and collaboration between space agencies and the pharmaceutical industry are essential for developing space-specific pharmaceuticals to ensure astronaut health and isuccess in future deep-space exploration. The objectives of this review are to investigate novel formulation and delivery technologies created to address these difficulties in microgravity settings, clarify the physicochemical and biological processes influencing drug efficacy, and investigate the elements causing pharmaceutical instability in space.