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<p>Ripe Papaya Pectin, a type of plant polysaccharides, has been shown to have a number of therapeutic benefits, including the ability to treat cancer. Ripe Papaya Pectin extracted from intermediate phases of papaya ripening markedly decreased cell viability, induced necroptosis, and delayed culture wound closing in three types of immortalized cancer cell lines. Additionally, studies have demonstrated that pectin specifically targets cancer cells by acting as a strong inducer of cell-cycle arrest and programmed cell death. Ripe Papaya Pectin can increase reactive oxygen species damage to trigger cancer cell death while reducing oxidative stress to preserve cellular homeostasis. Pectin’s anticancer effect is attributed to its regulation of many signaling cascades, including mitogen-activated protein kinase signaling, transcriptional activator signaling, and signal transduction. Ripe Papaya Pectin’s unique physicochemical characteristics and abundance of changeable functional groups make it an excellent carrier for anti-cancer medication delivery systems. Research also showed that pectin acts as a potent inducer of programmed cell death and cell-cycle arrest, thereby selectively targeting cancer cells. Overall, Pectin represents a promising, biocompatible platform that unites intrinsic anticancer properties with advanced delivery capabilities, rigorous standardization and clinical validation are the next steps toward therapeutic translation. This review article highlights pectin in various cancer treatment, including its usage as a pharmacological agent and an oncotherapeutic delivery system.</p><p></p>

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Mechanistic insights and emerging role of ripe papaya derived pectin as a natural polymer in cancer prevention and therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月5日

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  • Priya Patel,
  • Dhwani Bhatt,
  • Vivek Jasani,
  • Bhupendra Prajapati

摘要

Ripe Papaya Pectin, a type of plant polysaccharides, has been shown to have a number of therapeutic benefits, including the ability to treat cancer. Ripe Papaya Pectin extracted from intermediate phases of papaya ripening markedly decreased cell viability, induced necroptosis, and delayed culture wound closing in three types of immortalized cancer cell lines. Additionally, studies have demonstrated that pectin specifically targets cancer cells by acting as a strong inducer of cell-cycle arrest and programmed cell death. Ripe Papaya Pectin can increase reactive oxygen species damage to trigger cancer cell death while reducing oxidative stress to preserve cellular homeostasis. Pectin’s anticancer effect is attributed to its regulation of many signaling cascades, including mitogen-activated protein kinase signaling, transcriptional activator signaling, and signal transduction. Ripe Papaya Pectin’s unique physicochemical characteristics and abundance of changeable functional groups make it an excellent carrier for anti-cancer medication delivery systems. Research also showed that pectin acts as a potent inducer of programmed cell death and cell-cycle arrest, thereby selectively targeting cancer cells. Overall, Pectin represents a promising, biocompatible platform that unites intrinsic anticancer properties with advanced delivery capabilities, rigorous standardization and clinical validation are the next steps toward therapeutic translation. This review article highlights pectin in various cancer treatment, including its usage as a pharmacological agent and an oncotherapeutic delivery system.