Scholarlink

<p>Repeated pancreatic insults and inflammation can lead to the development of pancreatitis. In this study, the therapeutic potential of a nano-formulated metformin drug with chitosan (Cs-Met NPs) and/or low doses of γ-irradiation (IR) was evaluated against acute pancreatitis (AP) induced by L-arginine in an animal model. Thirty adult Wistar rats were randomly divided into five groups: normal control, L-arginine-treated (AP), AP + IR, AP + Cs-Met NPs, and AP + IR + Cs-Met NPs. Histopathological examination of the pancreas was performed, and biochemical parameters including serum amylase and lipase levels, random blood glucose (RBS), plasma insulin levels, insulin-like growth factor 1 (IGF-1), tumor necrosis factor-alpha (TNF-α), interleukins (IL-6, IL-8, IL-10), and C-reactive protein (CRP) were measured. L-arginine treatment significantly elevated serum amylase and lipase levels, as well as IL-6, IL-8, TNF-α, RBS, and CRP levels. It also substantially decreased IL-10, insulin, and IGF-1 levels. Microscopic examination revealed loss of pancreatic lobular architecture, marked fibrosis, acinar cell degeneration, inflammation, and edema. Administration of Cs-Met NPs and/or low-dose γ-irradiation markedly improved both the biochemical parameters and histopathological features.</p><p><b>Conclusion: </b>Nano-formulated metformin and/or low-dose γ-irradiation demonstrated significant therapeutic effects in a rat model of L-arginine-induced acute pancreatitis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Relieve acute pancreatitis in Wistar rats subjected to nano-formulated metformin drug with Chitosan and/or low doses γ-Irradiation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月15日

查看全文
  • Neamat H. Ahmed,
  • Mohamed Mosleh,
  • Faten Zahran

摘要

Repeated pancreatic insults and inflammation can lead to the development of pancreatitis. In this study, the therapeutic potential of a nano-formulated metformin drug with chitosan (Cs-Met NPs) and/or low doses of γ-irradiation (IR) was evaluated against acute pancreatitis (AP) induced by L-arginine in an animal model. Thirty adult Wistar rats were randomly divided into five groups: normal control, L-arginine-treated (AP), AP + IR, AP + Cs-Met NPs, and AP + IR + Cs-Met NPs. Histopathological examination of the pancreas was performed, and biochemical parameters including serum amylase and lipase levels, random blood glucose (RBS), plasma insulin levels, insulin-like growth factor 1 (IGF-1), tumor necrosis factor-alpha (TNF-α), interleukins (IL-6, IL-8, IL-10), and C-reactive protein (CRP) were measured. L-arginine treatment significantly elevated serum amylase and lipase levels, as well as IL-6, IL-8, TNF-α, RBS, and CRP levels. It also substantially decreased IL-10, insulin, and IGF-1 levels. Microscopic examination revealed loss of pancreatic lobular architecture, marked fibrosis, acinar cell degeneration, inflammation, and edema. Administration of Cs-Met NPs and/or low-dose γ-irradiation markedly improved both the biochemical parameters and histopathological features.

Conclusion: Nano-formulated metformin and/or low-dose γ-irradiation demonstrated significant therapeutic effects in a rat model of L-arginine-induced acute pancreatitis.