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<p>This study examined the antibacterial and antileishmanial activities of the essential oil extracted from the <i>Aster peduncularis</i> Wall. Ex Nees. The antibacterial activity of this essential oil was studied against five human pathogen bacteria (<i>Salmonella typhimurium (</i>MTCC No.3224), <i>Pseudomonas aeruginosa (</i>MTCC No. 424), <i>Bacillus subtilis (</i>MTCC No. 441), <i>Escherichia coli (</i>MTCC No. 443), <i>Klebsiella pneumoniae (</i>MTCC No. 3348) and six plant pathogenic bacteria (<i>Xanthomonas campestris (</i>BB0006), <i>Xanthomonas oryzae (</i>BH0007), <i>Ralstonia solanacearum (</i>BI0012), <i>Erwinia crysanthemi (</i>KUMSCC 328), <i>Xanthomonas phaseoli</i> (KUMSCC 327), <i>Agrobacterium tumefaciens (</i>MTCC No. 609) using disc diffusion and broth microdilution method. Among, human bacterial strain, <i>P</i>. <i>aeruginosa</i>, was the most effective for oil (13.50 mm, MIC 75 µl/ml), followed by <i>E</i>. <i>coli</i> (13.05 mm, MIC 75 µl/ml), <i>S</i>. <i>Typhimurium</i> (10.40 mm, MIC 100 µl/ml), <i>B</i>. <i>subtilis</i> (10.20 mm, MIC 100 µl/ml) and <i>K</i>. <i>pneumonia</i> (10.20 mm, MIC 100 µl/ml). Similary among plant pathogens, <i>X</i>. <i>phaseoli</i> (18.50 mm, MIC 50 µl/ml) had the most antibacterial activity, followed by <i>R</i>. <i>solanacearum</i> (17.90 mm, MIC 50 µl/ml) and <i>E</i>. <i>chrysanthem</i>um (13.50 mm, MIC 75 µl/ml). The antileishmanial activity of essential oils with promastigotes and intracellular amastigotes form of <i>Leishmania donovani</i> (Dd8) was also studied. EO was safer on the J774.A1 macrophages and lethal to promastigotes and intracellular amastigotes at different concentrations (10, 50, and 100 µg/ml). These findings support the traditional uses of <i>A. peduncularis</i> and suggest its potential as a natural remedy for bacterial infections and leishmaniasis. </p>

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Aster peduncularis Wall. Ex. Nees: in-vitro antibacterial and antileishmanial activities of essential oil from India

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  • 发表日期：

    2025年7月31日

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  • Bhawana Pant,
  • Manisha Bisht,
  • Devendra Singh Dhami

摘要

This study examined the antibacterial and antileishmanial activities of the essential oil extracted from the Aster peduncularis Wall. Ex Nees. The antibacterial activity of this essential oil was studied against five human pathogen bacteria (Salmonella typhimurium (MTCC No.3224), Pseudomonas aeruginosa (MTCC No. 424), Bacillus subtilis (MTCC No. 441), Escherichia coli (MTCC No. 443), Klebsiella pneumoniae (MTCC No. 3348) and six plant pathogenic bacteria (Xanthomonas campestris (BB0006), Xanthomonas oryzae (BH0007), Ralstonia solanacearum (BI0012), Erwinia crysanthemi (KUMSCC 328), Xanthomonas phaseoli (KUMSCC 327), Agrobacterium tumefaciens (MTCC No. 609) using disc diffusion and broth microdilution method. Among, human bacterial strain, P. aeruginosa, was the most effective for oil (13.50 mm, MIC 75 µl/ml), followed by E. coli (13.05 mm, MIC 75 µl/ml), S. Typhimurium (10.40 mm, MIC 100 µl/ml), B. subtilis (10.20 mm, MIC 100 µl/ml) and K. pneumonia (10.20 mm, MIC 100 µl/ml). Similary among plant pathogens, X. phaseoli (18.50 mm, MIC 50 µl/ml) had the most antibacterial activity, followed by R. solanacearum (17.90 mm, MIC 50 µl/ml) and E. chrysanthemum (13.50 mm, MIC 75 µl/ml). The antileishmanial activity of essential oils with promastigotes and intracellular amastigotes form of Leishmania donovani (Dd8) was also studied. EO was safer on the J774.A1 macrophages and lethal to promastigotes and intracellular amastigotes at different concentrations (10, 50, and 100 µg/ml). These findings support the traditional uses of A. peduncularis and suggest its potential as a natural remedy for bacterial infections and leishmaniasis.