Scholarlink

Objectives <p>The increasing prevalence of <i>Plasmodium</i> species resistance to conventional antimalarial drugs has spurred a surge in comprehensive research on the use of medicinal plants for malaria treatment. This study assessed the in vivo antimalarial efficacy of alkaloid and flavonoid extract from stem and leaves of <i>Phyllanthus amarus</i> plant.</p> Methods <p>Different extracts (alkaloids, flavonoids and ethanol extracts) were done on the leaves and stem of <i>P. amarus</i>. The extracts were orally administered at varying doses of 150, 300, and 450&#xa0;mg/kg body weight and the level of parasitaemia in mice were determined.</p> Results <p>Results show significant (p &lt; 0.05) reduction in parasite growth after treatment with the extracts in vivo in a dose-dependent manner when compared with the standard chloroquine drug.&#xa0;However, treatment with 450&#xa0;mg/kg of ethanol extract of stem and leaves of <i>P. amarus</i> indicated a better antiplasmodial activity.</p> Conclusions <p>The findings of this study showed that both flavonoids and alkaloids extracts of <i>P. amarus</i> may suppressed <i>P. berghei</i> development in mice. This may support its usage as traditional antiplasmodial plant.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

In vivo antiplasmodial activity of alkaloids, flavonoids and ethanol extracts from stem and leaves of Phyllanthus amarus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月31日

查看全文
  • Solomon Ugochukwu Okom,
  • Joel Okpoghono,
  • Innocent Onyesom

摘要

Objectives

The increasing prevalence of Plasmodium species resistance to conventional antimalarial drugs has spurred a surge in comprehensive research on the use of medicinal plants for malaria treatment. This study assessed the in vivo antimalarial efficacy of alkaloid and flavonoid extract from stem and leaves of Phyllanthus amarus plant.

Methods

Different extracts (alkaloids, flavonoids and ethanol extracts) were done on the leaves and stem of P. amarus. The extracts were orally administered at varying doses of 150, 300, and 450 mg/kg body weight and the level of parasitaemia in mice were determined.

Results

Results show significant (p < 0.05) reduction in parasite growth after treatment with the extracts in vivo in a dose-dependent manner when compared with the standard chloroquine drug. However, treatment with 450 mg/kg of ethanol extract of stem and leaves of P. amarus indicated a better antiplasmodial activity.

Conclusions

The findings of this study showed that both flavonoids and alkaloids extracts of P. amarus may suppressed P. berghei development in mice. This may support its usage as traditional antiplasmodial plant.

Graphical Abstract