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<p>A unique asymmetric Schiff base compound originated from thenil underwent synthesis and characterization via analytical and spectroscopic methods. The compound was obtained through thenil (Di-2-thienylethanedione) and 1, 2-diaminotoluene reaction using standard synthetic procedures in various solvents. The compound displayed an asymmetric structure and was devoid of all symmetry elements. Antibacterial activity of the synthesized compounds was performed by it’s biological efficacy against S. aureus and S. typhi in-vitro agar-well diffusion testing as compared to doxycycline. The prepared compound exhibited potential as a superior antimicrobial drug candidate, although further scrutiny and evaluation as opposed to other trademark compounds remains a necessary step to evaluate the real potential of the molecule as a potential therapeutics against a variety of infectious diseases.</p>

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An antibacterial agent based on diamine conjugated thenil Schiff Base: synthesis, crystal structure, and activity studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月12日

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  • Nidhi,
  • Siddharam,
  • Devendra Pratap Rao,
  • Amit Kumar Gautam,
  • Ashish Verma,
  • Yashveer Gautam,
  • Sanjay Singh,
  • Chandra Prakash Singh,
  • Alok Kumar Srivastava,
  • Shiv Govind Prasad

摘要

A unique asymmetric Schiff base compound originated from thenil underwent synthesis and characterization via analytical and spectroscopic methods. The compound was obtained through thenil (Di-2-thienylethanedione) and 1, 2-diaminotoluene reaction using standard synthetic procedures in various solvents. The compound displayed an asymmetric structure and was devoid of all symmetry elements. Antibacterial activity of the synthesized compounds was performed by it’s biological efficacy against S. aureus and S. typhi in-vitro agar-well diffusion testing as compared to doxycycline. The prepared compound exhibited potential as a superior antimicrobial drug candidate, although further scrutiny and evaluation as opposed to other trademark compounds remains a necessary step to evaluate the real potential of the molecule as a potential therapeutics against a variety of infectious diseases.