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<p>Breast cancer (BC) is one of the leading causes of death globally, resulting in 2.26 million cases worldwide. Treatments to downregulate these tumor cells include surgery, immunotherapy, and chemotherapy. However, habituation is expressed by the tumor cells after using the latter. Different plants have been used to treat diseases ranging from bacterial infection to cancer. Natural health products confirmed to be potent and still undergoing clinical trials include the dandelion plant, also known as&#xa0;<i>Taraxacum officinale</i>. This study evaluated Dandelion root extract's (DRE) antioxidant, antimicrobial, and cytotoxic effects. The Gas Chromatography-Mass Spectrometry (GC–MS) result revealed the presence of bioactive compounds such as P-hydroxybenzoic, chlorogenic acid, vanillic acid, caffeic acid, lupeol, leutolin, apigenin, coumestrol and much more that are present in the DRE extract. Antioxidant activity using a diphenylpicryl hydrazine (DPPH) scavenging assay was employed, and the result suggested a stable radical IC<sub>50</sub> value of 2.860 ± 0.001&#xa0;mg/mL. Trypan blue exclusion assay was used to determine the cytotoxic effect on MDA-MB-231 cells. Antimicrobial activity was assessed by disc diffusion assay, and the average diameter values obtained were 25&#xa0;mm for gentamicin. No antimicrobial activity was observed for the extracts at different concentrations. DRE showed no inhibitory effect against two gram-negative and gram-positive bacteria pathogens. Our study indicates that DRE has proven novel in killing breast cancer cells, has a mildly vigorous antioxidant activity to scavenge free radicals, and has no inhibitory effect against some bacteria.</p>

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Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月13日

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  • Ridwan Olanrewaju Shittu,
  • Ismaila Ceesay,
  • Pwadubashiyi Coston Pwavodi

摘要

Breast cancer (BC) is one of the leading causes of death globally, resulting in 2.26 million cases worldwide. Treatments to downregulate these tumor cells include surgery, immunotherapy, and chemotherapy. However, habituation is expressed by the tumor cells after using the latter. Different plants have been used to treat diseases ranging from bacterial infection to cancer. Natural health products confirmed to be potent and still undergoing clinical trials include the dandelion plant, also known as Taraxacum officinale. This study evaluated Dandelion root extract's (DRE) antioxidant, antimicrobial, and cytotoxic effects. The Gas Chromatography-Mass Spectrometry (GC–MS) result revealed the presence of bioactive compounds such as P-hydroxybenzoic, chlorogenic acid, vanillic acid, caffeic acid, lupeol, leutolin, apigenin, coumestrol and much more that are present in the DRE extract. Antioxidant activity using a diphenylpicryl hydrazine (DPPH) scavenging assay was employed, and the result suggested a stable radical IC50 value of 2.860 ± 0.001 mg/mL. Trypan blue exclusion assay was used to determine the cytotoxic effect on MDA-MB-231 cells. Antimicrobial activity was assessed by disc diffusion assay, and the average diameter values obtained were 25 mm for gentamicin. No antimicrobial activity was observed for the extracts at different concentrations. DRE showed no inhibitory effect against two gram-negative and gram-positive bacteria pathogens. Our study indicates that DRE has proven novel in killing breast cancer cells, has a mildly vigorous antioxidant activity to scavenge free radicals, and has no inhibitory effect against some bacteria.