Laser photostability of chitosan coated gold-GO nanocomposite and its role as a nano-therapeutic agent for control breast cancer growth

As the global cancer burden increases, it is critical to develop alternative treatments that produce minimal side effects, owing to its optical, thermal, and biological anticancer and biomedical applications of graphene and its nanocomposites. researchers have devoted the past few years to developing graphene/polymer and graphene/metal nanocomposites.

Here a simple, highly stable, non-toxic, eco- friendly chitosan gold nanoparticles (Cs-AuNPs) and its nanocomposites with graphene oxide nanosheets (GO) to form novel photostable (GO/AuNPs) nanocomposites. The prepared nanomaterials were characterized by UV–Vis, FTIRs, TEM and Raman as shown in graphical abstract. In addition, the anticancer efficiency of the prepared nanomaterials in breast cell lines (MCF7, T47D, MDA-MB-468 and MDA-MB-231) using SRP assay were evaluated.

Results revealed that Cs-AuNPs bound with the GO sheets via electrostatic interaction with high stability with uniform decoration. A new FTIRs peak of high intensity was found in the GO/Au nanocomposite confirming the decoration of Cs-AuNPs on the surface of the GO layers. GO/Au nanocomposite has a significant cytotoxic effect on breast cell lines as compared to GO only.

This work opens perceptions for translational applications of GO/Au nanocomposite on cancer cell lines, future work is to use the prepared nanocomposite in photothermal chemotherapy combined treatment.