Psychiatrische Syndrome bei multipler Sklerose

Psychiatric disorders are the most common comorbidities in patients with multiple sclerosis (MS) and show higher prevalences compared to the general population. The most frequently observed disorders include depressive and anxiety disorders, bipolar disorders, and psychotic conditions. Overall, it has been found that despite specific and partially validated diagnostic tools, psychiatric comorbidities in MS are often underdiagnosed and undertreated. Controlled clinical studies on the efficacy of psychopharmacological treatment addressed only depressive disorders in MS. Due to the multifactorial nature of psychiatric disorders, differentiating between coincidences, comorbidities, medication-induced, or organically caused disorders (e.g., a psychiatric relapse) is complex. The assessment and treatment of psychiatric comorbidities in MS are clinically relevant, frequently challenging, and require an interdisciplinary approach.