<p>The characteristic unorthodox method of waste collection by informal waste collectors (IWCs) makes them vulnerable to disease infection, which necessitates the need for them to seek medical care constantly. This paper examines the health-seeking behaviour of IWCs and the factors influencing their behavioural patterns in Abeokuta, Nigeria. A structured questionnaire was used to obtain information from 121 randomly selected IWCs. Frequencies and percentages, and the Relative Importance Index (RII) were used to analyse the data and statistically measure the factors influencing the health-seeking behaviour of the IWCs. Cough and catarrh (18.2%), physical injuries (17.3%), dysentery (8.2%), pneumonia (7.4%) and Malaria (5.9%) were the common health challenges of the IWCs; 68.6% did not use protective equipment during operation; 91.3% did not seek modern healthcare during illness. The results of the RII analysis indicate that, in rank order, income (0.731), severity of sickness (0.713), proximity (0.646), duration of illness (0.568), and education (0.531), are the major factors influencing the health-seeking behaviour of the IWCs. The health challenges of the IWCs are largely connected to the non-use of protective equipment and unwillingness to seek modern healthcare. Raising awareness among the IWCs on the need to seek modern healthcare during illness is recommended.</p>