<p>The paper develops and proposes a magnetofluidic vibration isolation system that incorporates elastic elements designed as zig–zag springs made from elastic isotropic rectangular plates of steel grade 60S2A. A review and analysis of the applicability of vibration isolation systems based on various viscoelastic materials, such as metallic, piezoelectric, polymer composite and magnetorheological ones, has been carried out. As a result of the analysis, it was found that the most effective method of reducing vibration activity on board spacecraft with precision devices and equipment is to use the magnetorheological effect of a magnetic fluid, which is due to its many advantages over other materials. The main criteria for a magnetofluidic vibration isolation system are considered, on the basis of which mathematical studies have been performed using specially developed algorithmic software to determine the maximum equivalent stresses and first natural frequencies of oscillation for various geometric parameters and the number of springs in the vibration isolation system design, taking into account the inclusion of round and square holes. Experimental studies have been conducted aimed at reducing the effects of vibration disturbances on board spacecraft generated by a reaction wheel using the developed magnetofluidic vibration isolation system and without it.</p>