Scholarlink

Background <p>Acute eosinophilic pneumonia (AEP) is a rare but potentially life-threatening condition characterized by respiratory distress, pulmonary infiltrates, and eosinophilic infiltration of the lungs. While smoking and environmental exposures are well-established triggers, drug-induced AEP, particularly following intramuscular progesterone (IMP) used during in vitro fertilization (IVF), is infrequently reported.</p> Objective <p>To report a case of IMP-associated AEP and conduct a literature review of published cases in the context of IVF.</p> Methods <p>We conducted a structured search of PubMed, Google Scholar, ResearchGate, and the Directory of Open Access Journals for articles published through July 23, 2025, using keywords such as “eosinophilic pneumonia,” “progesterone,” and “IVF.” We included English-language case reports involving female patients diagnosed with AEP attributed to IMP for luteal phase support during in vitro fertilization.</p> Results <p>Nineteen cases of IMP-associated AEP were identified, including ours. All patients were women undergoing assisted reproduction (mean age 33.6&#xa0;years), with a mean symptom onset of 5.2&#xa0;weeks after IMP initiation. Dyspnea with bilateral infiltrates was the most common presentation; peripheral eosinophilia was variable, and bronchoalveolar lavage (BAL), when performed, showed 55–75% eosinophils. All patients recovered after discontinuation of IMP, with or without corticosteroids. Six pregnancies progressed to term, two losses were reported, and pregnancy outcomes were not available for the remaining cases.</p> Conclusion <p>IMP-induced AEP, although rare, should be considered in patients presenting with unexplained respiratory symptoms during IVF. Early recognition and discontinuation of the suspected offending agent, with appropriate use of corticosteroids when indicated, may facilitate clinical recovery and prevent further complications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Acute Eosinophilic Pneumonia Caused by Progesterone Administration: a Case Report and Review of the Literature

  • 期刊论文

  • 发表日期：

    2026年7月30日

查看全文
  • Bhargav P. Patel,
  • Shifa Karatela,
  • Paola Gutierrez-Gallegos,
  • Deepika Karki,
  • Abubakr A. Bajwa

摘要

Background

Acute eosinophilic pneumonia (AEP) is a rare but potentially life-threatening condition characterized by respiratory distress, pulmonary infiltrates, and eosinophilic infiltration of the lungs. While smoking and environmental exposures are well-established triggers, drug-induced AEP, particularly following intramuscular progesterone (IMP) used during in vitro fertilization (IVF), is infrequently reported.

Objective

To report a case of IMP-associated AEP and conduct a literature review of published cases in the context of IVF.

Methods

We conducted a structured search of PubMed, Google Scholar, ResearchGate, and the Directory of Open Access Journals for articles published through July 23, 2025, using keywords such as “eosinophilic pneumonia,” “progesterone,” and “IVF.” We included English-language case reports involving female patients diagnosed with AEP attributed to IMP for luteal phase support during in vitro fertilization.

Results

Nineteen cases of IMP-associated AEP were identified, including ours. All patients were women undergoing assisted reproduction (mean age 33.6 years), with a mean symptom onset of 5.2 weeks after IMP initiation. Dyspnea with bilateral infiltrates was the most common presentation; peripheral eosinophilia was variable, and bronchoalveolar lavage (BAL), when performed, showed 55–75% eosinophils. All patients recovered after discontinuation of IMP, with or without corticosteroids. Six pregnancies progressed to term, two losses were reported, and pregnancy outcomes were not available for the remaining cases.

Conclusion

IMP-induced AEP, although rare, should be considered in patients presenting with unexplained respiratory symptoms during IVF. Early recognition and discontinuation of the suspected offending agent, with appropriate use of corticosteroids when indicated, may facilitate clinical recovery and prevent further complications.