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Background <p>Glaucoma requires lifelong topical therapy, making medication adherence a persistent clinical challenge. However, the sociodemographic and clinical factors that influence this relationship are not well established. This study evaluated the relationship between medication adherence and quality of life in glaucoma patients and to identify the clinical and sociodemographic factors influencing this relationship.</p> Methods <p>This cross-sectional study included 78 patients attending routine follow-up at the Glaucoma Unit of a training and research hospital in Istanbul between March 1 and April 30, 2025. This strict two-month recruitment window was bounded by institutional administrative approval and fixed research project timelines. Data were collected via face-to-face questionnaires including sociodemographic and clinical questions, the General Medication Adherence Scale (GMAS), and the Modified GlauQOL-17 Scale. Mann–Whitney U, Kruskal–Wallis, and Spearman correlation tests were used; significance was set at <i>p</i> &lt; 0.05.</p> Results <p>The mean age was 64.47 ± 8.97&#xa0;years; 64.1% were female. Mean GMAS and Modified GlauQOL-17 scores were 30.69 ± 3.13 and 55,14 ± 11.18, respectively. 76.9% of participants demonstrated high medication adherence. A moderate positive correlation was found between adherence and quality of life (ρ = 0.374, 95% CI [0.185, 0.534], <i>p</i> &lt; 0.001). Female gender (<i>p</i> = 0.023) and non-working status (<i>p</i> = 0.010) negatively affected quality of life. Educational level, income, age, and diagnosis duration showed no significant effects.</p> Conclusion <p>A significant positive correlation exists between medication adherence and quality of life in glaucoma patients. However, the mean Modified GlauQOL-17 score of 55.14 ± 11.18 out of 72 points indicates that quality of life remains at a moderate level despite high adherence, suggesting that adherence alone is insufficient. Psychosocial factors, particularly among female patients and those lacking retirement security, should be incorporated into holistic glaucoma management strategies.</p>

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An Investigation into the Effect of Treatment Adherence on Quality of Life in Glaucoma Patients

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Yunus Emre Tüzün,
  • Zeynep Tüzün,
  • Nimet Emel Lüleci,
  • Ela Tuğçe Yetim,
  • İrem Yakşi,
  • Safvan Tutal,
  • Şule Meryem Şengün,
  • Betül İlkay Sezgin Akçay

摘要

Background

Glaucoma requires lifelong topical therapy, making medication adherence a persistent clinical challenge. However, the sociodemographic and clinical factors that influence this relationship are not well established. This study evaluated the relationship between medication adherence and quality of life in glaucoma patients and to identify the clinical and sociodemographic factors influencing this relationship.

Methods

This cross-sectional study included 78 patients attending routine follow-up at the Glaucoma Unit of a training and research hospital in Istanbul between March 1 and April 30, 2025. This strict two-month recruitment window was bounded by institutional administrative approval and fixed research project timelines. Data were collected via face-to-face questionnaires including sociodemographic and clinical questions, the General Medication Adherence Scale (GMAS), and the Modified GlauQOL-17 Scale. Mann–Whitney U, Kruskal–Wallis, and Spearman correlation tests were used; significance was set at p < 0.05.

Results

The mean age was 64.47 ± 8.97 years; 64.1% were female. Mean GMAS and Modified GlauQOL-17 scores were 30.69 ± 3.13 and 55,14 ± 11.18, respectively. 76.9% of participants demonstrated high medication adherence. A moderate positive correlation was found between adherence and quality of life (ρ = 0.374, 95% CI [0.185, 0.534], p < 0.001). Female gender (p = 0.023) and non-working status (p = 0.010) negatively affected quality of life. Educational level, income, age, and diagnosis duration showed no significant effects.

Conclusion

A significant positive correlation exists between medication adherence and quality of life in glaucoma patients. However, the mean Modified GlauQOL-17 score of 55.14 ± 11.18 out of 72 points indicates that quality of life remains at a moderate level despite high adherence, suggesting that adherence alone is insufficient. Psychosocial factors, particularly among female patients and those lacking retirement security, should be incorporated into holistic glaucoma management strategies.