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Objective <p>Coronary artery disease (CAD) is a major challenge in the current diagnostic system. Troponin T is one of the key markers for assessing damage due to CAD. There are various factors responsible for cardiac damage and the elevation of troponin levels. In this study, our primary aim was to determine the role of activated platelets in the pathophysiology of disease progression. We also analysed the levels of reactive oxygen species (ROS) and cytokines (IL-6 and TNF-α) to determine whether they help in platelet activation and the pathogenesis of CAD.</p> Methods <p>The study included 50 CAD patients with positive troponin T-test results and 50 matched healthy controls. ROS levels were assessed using DCFH-DA; platelet activation was assessed using CD marker CD42b expression; and cytokine levels were assessed using IL-6 and TNF-α levels.</p> Result <p>We found that troponin T-positive patients showed a significantly higher level of ROS, higher % expression of CD42b, and higher levels of IL-6 and TNF-α cytokines in the troponin T-positive group with respect to healthy controls.</p> Conclusion <p>These biomarkers were found to be significantly associated with CAD and may represent useful markers of the underlying inflammatory and thrombotic processes associated with the disease.</p>

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Platelet Activation, Oxidative Stress and Inflammatory Biomarkers in Troponin-T-Positive Patients with Coronary Artery Disease: A Case-Control Study

  • 期刊论文

  • 发表日期：

    2026年7月3日

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  • Sharique Ahmad,
  • Raushan Kumar,
  • Bashir Ahmad Mir,
  • Syed Tasleem Raza

摘要

Objective

Coronary artery disease (CAD) is a major challenge in the current diagnostic system. Troponin T is one of the key markers for assessing damage due to CAD. There are various factors responsible for cardiac damage and the elevation of troponin levels. In this study, our primary aim was to determine the role of activated platelets in the pathophysiology of disease progression. We also analysed the levels of reactive oxygen species (ROS) and cytokines (IL-6 and TNF-α) to determine whether they help in platelet activation and the pathogenesis of CAD.

Methods

The study included 50 CAD patients with positive troponin T-test results and 50 matched healthy controls. ROS levels were assessed using DCFH-DA; platelet activation was assessed using CD marker CD42b expression; and cytokine levels were assessed using IL-6 and TNF-α levels.

Result

We found that troponin T-positive patients showed a significantly higher level of ROS, higher % expression of CD42b, and higher levels of IL-6 and TNF-α cytokines in the troponin T-positive group with respect to healthy controls.

Conclusion

These biomarkers were found to be significantly associated with CAD and may represent useful markers of the underlying inflammatory and thrombotic processes associated with the disease.