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<p>Metabolic Metabolic syndrome (MetS), characterized by central obesity, dyslipidaemia, insulin resistance, and hypertension, is linked to right ventricular (RV) failure and pulmonary vascular dysfunction. While most research has focused on left ventricular failure, recent studies highlight the strong association between MetS and RV remodelling, including chamber dilation, reduced contractility, fibrosis, and capillary rarefaction. Endothelial damage, inflammation, and oxidative stress drive pulmonary vascular remodelling, and molecular pathways such as endothelin-1, angiotensin II, mTOR, and microRNAs contribute to RV fibrosis and apoptosis. Imaging techniques like echocardiography, MRI, and CT pulmonary angiography aid in early detection of RV alterations, emphasizing the need for timely interventions to prevent functional decline.</p>

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The Right Ventricle in Metabolic Syndrome: a Missing Piece in Pulmonary Vascular Pathophysiology

  • 期刊论文

  • 发表日期：

    2026年5月28日

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  • Talha Farooq,
  • Rooma Rehan,
  • Tayyaba Malik,
  • Muhammad Talha,
  • FNU Sawaira,
  • Muhammad Nouman Javed,
  • Abeer Riaz,
  • Jamil Nasrallah,
  • Riham Zubair,
  • Mohammad Eisa Ali,
  • Maleeha Pandit

摘要

Metabolic Metabolic syndrome (MetS), characterized by central obesity, dyslipidaemia, insulin resistance, and hypertension, is linked to right ventricular (RV) failure and pulmonary vascular dysfunction. While most research has focused on left ventricular failure, recent studies highlight the strong association between MetS and RV remodelling, including chamber dilation, reduced contractility, fibrosis, and capillary rarefaction. Endothelial damage, inflammation, and oxidative stress drive pulmonary vascular remodelling, and molecular pathways such as endothelin-1, angiotensin II, mTOR, and microRNAs contribute to RV fibrosis and apoptosis. Imaging techniques like echocardiography, MRI, and CT pulmonary angiography aid in early detection of RV alterations, emphasizing the need for timely interventions to prevent functional decline.