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Background <p>Vitamin D deficiency (VDD) is increasingly recognized as a potential contributor to cardiovascular diseases (CVD). Emerging evidence indicates that low vitamin D (VD) status may exacerbate myocardial injury and enhance inflammatory responses in coronary artery diseases.</p> Aim <p>To investigate the relationship between VD status and cardiac injury as well as inflammatory biomarkers in acute coronary syndrome (ACS) patients presenting with ST-elevation myocardial infarction (STEMI).</p> Methodology <p>This prospective observational study recruited a cohort of 180 ACS patients with STEMI presented to the emergency department. Blood samples were collected before angioplasty and analyzed for serum VD, cardiac injury markers (troponin-I, CK-MB, LDH, myoglobin, myosin light chain-1, and whole blood choline), and inflammatory markers such as Interleukin (IL)-6, IL-8, IL-10, IL-33, and interferon (IFN)-γ.</p> Results <p>Study findings revealed that most participants, 61.1% (<i>n</i> = 110), were VD deficient (≤ 20 ng/mL). VD showed marked negative associations with LDH (<i>β=-0.39</i>), WBCHO (<i>β=-0.29</i>), IFN-γ (<i>β=-0.40</i>), IL-33 (<i>β=-0.35</i>), IL-8 (<i>β=-0.33</i>), CRP (β=-0.16), and IL-6 (<i>β=-0.15</i>). ACS patients with STEMI having VDD (&lt; 20 ng/mL) had significantly higher levels of LDH, Myoglobin, MLC-1, WBCHO, CRP, IL-6, -8, -33 and IFN-γ (<i>p</i> &lt; 0.05) compared to those having VD levels &gt; 20 ng/mL. Further, Trop-I &amp; CK-MB levels were non-significantly higher in VDD patients.</p> Conclusion <p>VD deficiency and insufficiency were highly prevalent among ACS patients with STEMI. These associations were more significant with inflammation than cardiac injury, suggesting that low VD status may contribute to greater inflammatory response during STEMI. However, prospective research is needed to validate these associations and their clinical implications.</p>

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Vitamin D Deficiency Among Indian Acute Coronary Syndrome Patients Admitted in Coronary Care Unit: Association With Inflammation and Disease Severity

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Harlokesh Narayan Yadav,
  • Aatish Rengan,
  • D. Chidanand,
  • Gauri Chaturvedi,
  • Satnam Singh,
  • Akshay Kumar,
  • M. A. Khan,
  • Rajiv Narang

摘要

Background

Vitamin D deficiency (VDD) is increasingly recognized as a potential contributor to cardiovascular diseases (CVD). Emerging evidence indicates that low vitamin D (VD) status may exacerbate myocardial injury and enhance inflammatory responses in coronary artery diseases.

Aim

To investigate the relationship between VD status and cardiac injury as well as inflammatory biomarkers in acute coronary syndrome (ACS) patients presenting with ST-elevation myocardial infarction (STEMI).

Methodology

This prospective observational study recruited a cohort of 180 ACS patients with STEMI presented to the emergency department. Blood samples were collected before angioplasty and analyzed for serum VD, cardiac injury markers (troponin-I, CK-MB, LDH, myoglobin, myosin light chain-1, and whole blood choline), and inflammatory markers such as Interleukin (IL)-6, IL-8, IL-10, IL-33, and interferon (IFN)-γ.

Results

Study findings revealed that most participants, 61.1% (n = 110), were VD deficient (≤ 20 ng/mL). VD showed marked negative associations with LDH (β=-0.39), WBCHO (β=-0.29), IFN-γ (β=-0.40), IL-33 (β=-0.35), IL-8 (β=-0.33), CRP (β=-0.16), and IL-6 (β=-0.15). ACS patients with STEMI having VDD (< 20 ng/mL) had significantly higher levels of LDH, Myoglobin, MLC-1, WBCHO, CRP, IL-6, -8, -33 and IFN-γ (p < 0.05) compared to those having VD levels > 20 ng/mL. Further, Trop-I & CK-MB levels were non-significantly higher in VDD patients.

Conclusion

VD deficiency and insufficiency were highly prevalent among ACS patients with STEMI. These associations were more significant with inflammation than cardiac injury, suggesting that low VD status may contribute to greater inflammatory response during STEMI. However, prospective research is needed to validate these associations and their clinical implications.