<p>Ocular hypotony is characterized by abnormally low intraocular pressure. It is an uncommon condition, usually arising secondary to ophthalmic inflammation, trauma, or surgery, whereas its occurrence independent of intraocular pathology is extremely rare. This review systematically identified and analyzed 13 published cases of ocular hypotony following non-ocular operations, particularly cardiothoracic surgery and neurosurgical or neurovascular procedures. The pathophysiology of ocular hypotony in this setting is multifactorial and likely involves a complex interplay between surgery- and anesthesia-related factors that collectively alter aqueous humor dynamics, intraocular blood volume, and extraocular muscle tone. Ophthalmologists should be aware of this rare complication, as they may be consulted postoperatively for patients presenting with unilateral or bilateral globe deformation with a wrinkled, deflated corneal surface. Management focuses on reassurance regarding the benign nature of the condition, close observation, and correction of systemic parameters, such as blood pressure and arterial blood gases, when abnormal. The prognosis is excellent, with normalization of intraocular pressure and complete resolution typically expected within 24–48&#xa0;h.</p>