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Introduction <p>Granulomatosis with polyangiitis (GPA) is a rare and potentially fatal systemic disease that is characterized by&#xa0;necrotizing vasculitis of small and medium vessels. The respiratory system is the most affected but it also affects the renal system.</p> Case Report <p>Sixty-seven-Year-old man has been suffering from nasal stuffiness and nasal discharge of thick mucous secretion for&#xa0;many years which led to bilateral middle ear effusion for which he has been investigated and managed with frequent nasal lavage&#xa0;and suction and antibiotics but there was no complete recovery with relapse and remission. A few days later, he experienced chest&#xa0;tightness and hemoptysis with bluish discoloration of the tips of the fingers. A swab from the nasal secretion was sent for&#xa0;microbiology which later came back as a heavy growth of streptococcus. CXR revealed multiple bilateral pulmonary nodules. CT&#xa0;Chest also confirms the presence of the pulmonary nodules. CT-Sinuses shows opacification of multiple sinuses. bronchoscopy&#xa0;revealed abnormal mucosal erythema and purulent secretions with fresh bleeding. An endobronchial biopsy was taken for&#xa0;histopathology study which revealed features of necrosis with extensive acute and chronic inflammatory infiltrates.</p> Conclusions <p>Early diagnosis and appropriate treatment are crucial in preventing the progression of this disease to an irreversible stage, but&#xa0;unfortunately difficult to achieve because of the multiplicity of presenting symptoms and ambiguous histological features.</p>

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Otorhinolaryngological Manifestations of Granulomatosis with Polyangiitis

  • 期刊论文

  • 发表日期：

    2025年12月6日

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  • Khalid Mahmoud Sayed Seedahmed,
  • Samra Elbashir,
  • Esha Saqib

摘要

Introduction

Granulomatosis with polyangiitis (GPA) is a rare and potentially fatal systemic disease that is characterized by necrotizing vasculitis of small and medium vessels. The respiratory system is the most affected but it also affects the renal system.

Case Report

Sixty-seven-Year-old man has been suffering from nasal stuffiness and nasal discharge of thick mucous secretion for many years which led to bilateral middle ear effusion for which he has been investigated and managed with frequent nasal lavage and suction and antibiotics but there was no complete recovery with relapse and remission. A few days later, he experienced chest tightness and hemoptysis with bluish discoloration of the tips of the fingers. A swab from the nasal secretion was sent for microbiology which later came back as a heavy growth of streptococcus. CXR revealed multiple bilateral pulmonary nodules. CT Chest also confirms the presence of the pulmonary nodules. CT-Sinuses shows opacification of multiple sinuses. bronchoscopy revealed abnormal mucosal erythema and purulent secretions with fresh bleeding. An endobronchial biopsy was taken for histopathology study which revealed features of necrosis with extensive acute and chronic inflammatory infiltrates.

Conclusions

Early diagnosis and appropriate treatment are crucial in preventing the progression of this disease to an irreversible stage, but unfortunately difficult to achieve because of the multiplicity of presenting symptoms and ambiguous histological features.