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Purpose <p>This study aimed to compare laparotomic (LT) and laparoscopic (LS) approaches in patients diagnosed with stage I endometrioid endometrial cancer (EEC) who were treated at our institution.</p> Methods <p>The study included 458 patients with stage I EEC who underwent surgery. Patients were categorized into two groups based on the surgical approach: LT (Group 1, n = 329, 71.8%) and LS (Group 2, n = 129, 28.2%). Clinical, histopathological, and survival data were compared between the groups.</p> Results <p>The median follow-up durations were 62&#xa0;months (3–136) for Group 1 and 56&#xa0;months (5–134) for Group 2. The two groups were similar in terms of age and body mass index (BMI) (p &gt; 0.05). The 5-year disease-free survival (DFS) rates were 96.0% in Group 1 and 96.9% in Group 2 (p = 0.185), while the 5-year overall survival (OS) rates were 96.4% and 92.6%, respectively (p = 0.186). There was no statistically significant between-group difference in recurrence [6.4% (21/329) vs 1.6% (2/129) respectively, p = 0.08]. In univariate regression analysis, BMI, type of surgery, stage, depth of myometrial invasion (MI), number of pelvic and paraaortic lymph nodes, total lymph node count, and receipt of adjuvant therapy were statistically significant (p &lt; 0.05). However, multivariate analysis identified none of these variables as independent risk factors (p &gt; 0.05).</p> Conclusion <p>In women with stage I EEC, the choice between laparoscopic and laparotomic hysterectomy did not result in significant differences in DFS or OS. These findings support the use of laparoscopic hysterectomy as an effective surgical option in this patient population.</p>

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Comparison of Long-Term Outcomes of Laparoscopic and Laparotomic Approaches in Patients with Early-Stage Endometrioid Endometrial Cancer

  • 期刊论文

  • 发表日期：

    2025年9月26日

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  • Özgün Yıldırım,
  • Hande Nur Öncü,
  • Neslihan Öztürk,
  • Aygül Yıldırım,
  • Vakkas Korkmaz

摘要

Purpose

This study aimed to compare laparotomic (LT) and laparoscopic (LS) approaches in patients diagnosed with stage I endometrioid endometrial cancer (EEC) who were treated at our institution.

Methods

The study included 458 patients with stage I EEC who underwent surgery. Patients were categorized into two groups based on the surgical approach: LT (Group 1, n = 329, 71.8%) and LS (Group 2, n = 129, 28.2%). Clinical, histopathological, and survival data were compared between the groups.

Results

The median follow-up durations were 62 months (3–136) for Group 1 and 56 months (5–134) for Group 2. The two groups were similar in terms of age and body mass index (BMI) (p > 0.05). The 5-year disease-free survival (DFS) rates were 96.0% in Group 1 and 96.9% in Group 2 (p = 0.185), while the 5-year overall survival (OS) rates were 96.4% and 92.6%, respectively (p = 0.186). There was no statistically significant between-group difference in recurrence [6.4% (21/329) vs 1.6% (2/129) respectively, p = 0.08]. In univariate regression analysis, BMI, type of surgery, stage, depth of myometrial invasion (MI), number of pelvic and paraaortic lymph nodes, total lymph node count, and receipt of adjuvant therapy were statistically significant (p < 0.05). However, multivariate analysis identified none of these variables as independent risk factors (p > 0.05).

Conclusion

In women with stage I EEC, the choice between laparoscopic and laparotomic hysterectomy did not result in significant differences in DFS or OS. These findings support the use of laparoscopic hysterectomy as an effective surgical option in this patient population.