<p>Resource extraction commonly occurs in geographically remote locations, with tasks performed by mobile/rotational workers. During their shifts, workers commonly live on site in workforce camps. The nature of this work poses unique burdens on these workers’ mental and physical well-being and, indirectly, on their families. These workers often experience higher rates of mental and physical health conditions and frequently engage in maladaptive coping mechanisms, including alcohol and drug use. The elements that contribute to poor mental health include compressed work shifts with long days and often hard physical labour, separation from loved ones, isolation, the rhythms of camp life that lead to feelings of institutionalization, poor nutrition and sleep while living in camp, transitioning between work and home persona, and others. Workers often do not seek help for fear of job loss and a culture of stigma against mental health disorders. This review explores the literature of research performed on the mental health of these rotational workers and relies also on the expertise of stakeholders who have interacted with these workers in the Athabasca oil sands of Northern Alberta, Canada (a researcher, a critical incident responder, a union representative, and a camp operator). It discusses the burdens that rotational workers face that lead to poor mental and physical health, the roots of the culture of stigma in the resource extraction industries, and provides recommendations on improving outcomes. The authors recommend that all stakeholders (camp operators, employers, employees, and collective bargaining units) collaborate to (a) recognize the adverse conditions unique to rotational work, (b) generate solutions to decrease the impact of stressors, (c) prioritize the well-being of these workers and their families, and (d) shift the workplace culture to one where employees address their mental health concerns. Our modern society is highly dependent on the resource extraction industry. Recognizing and improving the well-being of these workers must become a priority.</p>